Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats

Озеров, А. А.; Багметова, В. В.; Chernysheva, Yu. V.; Tyurenkov, I. N.

doi:10.1007/s10517-016-3240-6

Cited by 9 publications

(7 citation statements)

References 2 publications

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“…Adolescent substance users show abnormalities in neurocognition, brain structure and brain function. 43 The findings of the present study showed that abuse of tramadol or cannabis alone caused antidepressant-like behaviour, impaired spatial memory, elevated 5-HT levels in the cerebral cortex and hippocampus, induced oxidative stress and apoptosis in brain tissue and deleteriously altered brain structure. Tramadol abuse had a potent antidepressant effect and a more potential to elicit oxidant stress than cannabis.…”

Section: Discussionsupporting

confidence: 46%

A study of the neurotoxic effects of tramadol and cannabis in adolescent male albino rats

et al. 2016

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Background: Adolescence is a critical period for cerebral development. Exposure to addictive substances during this phase leads to various alterations in brain functions that persist into adulthood. The present study was designed to study the neurotoxic effects of tramadol and cannabis, alone and in combination, in adolescent male albino rats by studying their behavioral, biochemical, and histopathological neurotoxic effects and their long–term consequences after withdrawal.Methods: For this purpose, 132 adolescent male albino rats were divided into 5 groups (22 rats/ group). Group I (negative control), received only regular diet and tap water to measure the basic parameters, Group II (positive control; IIA&IIB); IIA, gavaged with normal saline. IIB, gavaged with olive oil. Group III (tramadol), gavaged with tramadol (42, 84 and 168 mg/kg/day) in the first, second and third ten days of the study respectively. Group IV (cannabis), gavaged with hashish extract (92, 184 and 368 mg/kg/day) in the first, second and third ten days of the study respectively. Group V (tramadol+cannabis), gavaged with tramadol and hashish extract in the same doses as Group III&IV. By the end of the first month, the half number of rats was subjected to performing behavior tests. Specimens from the brain were taken for performing biochemical and histopathological studies. All remaining rats were held for another 4 weeks non–dosing spontaneous recovery period after withdrawal of the treatment and were evaluated again by the same previous parameters.Results: Abuse of tramadol or cannabis, alone and in combination, caused antidepressant effect (sucrose preference test), impaired spatial memory (Morris water maze), elevated serotonin levels in the cerebral cortex and hippocampus, induced oxidative stress (significantly elevated malondialdehyde level and reduced catalase activity) as well as deleteriously altered brain histopathology and marked increase in brain Caspase–3 expression. However, abuse of both tramadol and cannabis conferred more antidepressant effect but more neurotoxic effect. After withdrawal, the antidepressant effect was reversed, no improvement of the spatial memory, marked depletion of 5–HT, more improvement in antioxidants and apoptotic markers and incomplete regression of brain histopathological alteration resulted.Conclusions: Abuse of tramadol and cannabis, alone and in combination, induced neurotoxicity which proved behaviorally, biochemically and histopathologically.

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Section: Discussionsupporting

confidence: 46%

A study of the neurotoxic effects of tramadol and cannabis in adolescent male albino rats

et al. 2016

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“…Studies have found that reserpine is widely used in the modeling of depression, Parkinson's disease and schizophrenia (Fernandes et al, 2012;Park et al, 2018). The reserpine-induced depression rat model can be divided into two types, one for a low dose (i.p., 0.1-0.5 mg/kg) and one for a single high dose (i.p., 1-5 mg/kg) (Fernandes et al, 2012;Ozerov et al, 2016). According to the pre-experiment, a single dose of 4.0 mg/ kg reserpine induced depressive symptoms in model rats and was significantly more effective than a single dose of 0.3 mg/kg of reserpine; for example, to decrease the exercise activity in the OFT, to increase the exercise time in the FST and to reduce the sugar water preference in the SPT.…”

Section: Discussionmentioning

confidence: 98%

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

et al. 2020

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Depression is becoming a major public health concern worldwide. Si-Ni-San (SNS) is a famous formula in Traditional Chinese Medicine (TCM) with potent antidepressant effects. However, the antidepressant mechanism of SNS has not been clearly elucidated. This study was performed to verify whether the antidepressant effects of SNS were related to its anti-inflammatory effects, the levels of brain-derived neurotrophic factor (BDNF) and Cytochrome P450 (CYP450) enzymatic activity. In our study, behavioral tests such as the forced swim test, sucrose preference test and open-field test were evaluated to ensure the establishment of depressive rats. The levels of IL-1b, IL-6, and TNF-a in the serum, liver, and hippocampus of rats were measured by enzyme-linked immunosorbent assays (ELISA). Furthermore, the key proteins NF-kB, BDNF, and TrkB were analyzed by Western blot (WB) analysis in the hippocampus. In addition, CYP450 enzymatic activity analysis was performed using LC-MS/MS in conjunction with drug and statistics (DAS 3.0) after oral administration of six probe drugs. Our results showed that SNS attenuated reserpineinduced increases in IL-1b, IL-6, and TNF-a expression in the serum, liver, and hippocampus. The levels of NF-kB, BDNF, and TrkB in the hippocampus of depressive rats were also altered. According to the pharmacokinetic parameters, SNS had moderate inhibitory effects in the reserpine-induced depression model on CYP1A2, CYP2D1, CYP2E1, and CYP3A2, but no significant metabolic changes to CYP2C6 and CYP2D2. These findings suggested that SNS has a protective effect on reserpine-induced depressive rats, which may be related to the improvement of the inflammatory factors, the level of BDNF and the activity of CYP450 enzymes.

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“…Results of the 5HTP test support that FCS-304 could act through a pro-serotoninergic mechanism at the central level. In addition, given that forced swimming and reserpine tests are high sensitive to non-selective agents, among them, tricyclic antidepressants (32,33), it is reasonable to assume that imipramine shows a greater response in both assays, whereas FCS-304 is more effective against 5-HTP.…”

Section: Discussionmentioning

confidence: 99%

Serotonergic-like profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in mice and rats

Moreno

Suárez

Guerrero

2019

Vitae

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ANTECEDENTES: 4-propil-2H-benzo [h] -cromen-2-ona (FCS-304) es una cumarina semisintética con actividad inhibidora de MAO-A y resultados positivos en natación forzada y prueba de suspensión de cola en ratones, pero hasta ahora, no se ha estudiado en otros modelos de antidepresivos de detección en ratones y ratas.OBJETIVOS: El objetivo de este trabajo fue evaluar el efecto similar a la serotonina de FCS-304 en la prueba de 5-hidroxitriptófano (5-HTP) en ratones, en la prueba de desesperación del comportamiento en ratas y en la prueba de reserpina en ratas.MÉTODOS: Se evaluó la potenciación de 5-HTP (100 mg / kg, ip), sacudidas de cabeza inducidas en ratones, previamente tratados con FCS-304 (50-75-150 mg / Kg, po). La prueba de desesperación del comportamiento se realizó en ratas tratadas con FCS-304, registrando el tiempo de inmovilidad alcanzado por los animales sometidos a natación forzada. Se examinó el antagonismo de la ptosis inducida por reserpina en ratas, evaluando el nivel de cierre palpebral. La imipramina (30 mg / kg, po) y el vehículo (aceite de canola) sirvieron como controles positivos y negativos, respectivamente.RESULTADOS: FCS-304 potenció significativamente las contracciones en la cabeza inducidas por 5-HTP en ratones, de una manera dependiente de la dosis. En ratas, FCS-304 redujo significativamente el tiempo de inmovilidad en la prueba de desesperación conductual y antagonizó la ptosis inducida por reserpina.CONCLUSIÓN: Estos resultados agregan apoyo para proponer que el FCS-304 podría provocar efectos antidepresivos relacionados con la actividad inhibidora de MAO-A.

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Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats

Cited by 9 publications

References 2 publications

A study of the neurotoxic effects of tramadol and cannabis in adolescent male albino rats

A study of the neurotoxic effects of tramadol and cannabis in adolescent male albino rats

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

Serotonergic-like profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in mice and rats

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