Aim. To study the effect of blood thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate content on the manifestation of anticoagulant effect upon subcutaneous administration to rabbits. Materials and methods. The studies were fulfilled on outbred rabbits. The substance was administered subcutaneously in the dose of 35 mg/kg. The time of blood coagulation was determined using coagulometer “Minilab 701”, and blood concentration - by means of liquid micro-column chromatograph “Milichrom A-02”. Results. The obtained results prove that maximum concentration of the compound in blood and maximum anticoagulant effect is reached in 30 minutes after subcutaneous administration. The substance anticoagulant effect lasted for 120 minutes after its administration. At present, the compound concentration in blood is equal to 519.8 ± 145.41 ng/ml. Conclusions. The studied compound, when administered subcutaneously, is quickly absorbed and begins to render an anticoagulant effect. Efficacy of action of this compound depends on its blood concentration.
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