The study investigates the intravital high-field proton magnetic resonance spectroscopy and superimposed magnetic scanning of brain metabolism in 60 patients showing the association between demyelination activity and the inflammatory or degenerative stage of MS. It also educes Flicker noise phenomenon as a new indicator of a pathologic process progression. The data on the tissue respiration decrease, of the neurotransmitter hypometabolism, energy, and enzyme brain systems were collected to use as the therapy prediction and monitoring of MS.
Results of immunological blood count and liquor test taken from 76 patients with multiple sclerosis aged 33,6±2,7 were studied to determine genetic markers of locus HLA-drB1and asynchronous intrathecal synthesis ratio of immunoglobulin free light chain (К ƙ/ƛ), as well as state of mitochondrial electron transport chain and density of neurotransmitter receptors of brain cells. 12 laboratory Guinea pigs with experimental allergic encephalomyelitis were taken to conduct electron microscopy of ultrathin brain sections collected from animals at the peak of the disease. Weak association of immunological and genetic indicators and statistically significant morphofunctional abnormalities of mitochondrial appara- tus of brain cells as well as neurotransmitter deviations towards nociceptive processes with simultaneous weakening of central antinociceptive mechanisms was found. The conclusion is that patients with mul- tiple sclerosis have early pathologic aging so early geroprotective therapy is required.
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