Multiple Sclerosis. Justification of Geroprotective Therapy

Abstract

Results of immunological blood count and liquor test taken from 76 patients with multiple sclerosis aged 33,6±2,7 were studied to determine genetic markers of locus HLA-drB1and asynchronous intrathecal synthesis ratio of immunoglobulin free light chain (К ƙ/ƛ), as well as state of mitochondrial electron transport chain and density of neurotransmitter receptors of brain cells. 12 laboratory Guinea pigs with experimental allergic encephalomyelitis were taken to conduct electron microscopy of ultrathin brain sections collected from animals at the peak of the disease. Weak association of immunological and genetic indicators and statistically significant morphofunctional abnormalities of mitochondrial appara- tus of brain cells as well as neurotransmitter deviations towards nociceptive processes with simultaneous weakening of central antinociceptive mechanisms was found. The conclusion is that patients with mul- tiple sclerosis have early pathologic aging so early geroprotective therapy is required.