Organic chemistry and biology are considered the most privileged combinations in medicinal chemistry. The importance of organic molecules in the development of medications to treat a variety of fatal diseases is undeniably comprehensive. In recent years, scientists have worked hard to identify and synthesize medications that can be used to whiten the skin and treat skin diseases. Tyrosinase (EC 1.14.18.1) is a multi-copper enzyme which is widely distributed in nature, including plants, fungi, bacteria, and animals. It plays a significant role in melanogenesis and enzymatic browning in damaged fruits (Chang, 2009;Zolghadri et al., 2019). Tyrosinase acts as a catalyst in a two-step reaction, which occurs during the melanogenesis process: hydroxylation converts mono-phenol to orthodiphenol (o-diphenol), then the ortho-diphenol is oxidized and converted into ortho-quinone (o-quinone) (Ramsden & Riley, 2014). Melanin, which is produced by melanocytes during the process of melanogenesis, is the primary
In this study, a series of 1,3,4-thiadiazole-thiazolidinone derivatives (7a–j) were synthesized as carbonic anhydrase inhibitors. The in vitro carbonic anhydrase inhibitory activity of these synthesized compounds was determined and the...
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