Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies

Design, synthesis, and in vitro and in silico studies of 1,3,4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors

“…To determine the type of inhibition exhibited by compound 7i against carbonic anhydrase, a series of experiments were performed in the same manner as that described previously. 62,63 Compound 7i was selected for analysis based on the IC 50 results. Lineweaver–Burk plots were used for investigating the inhibition type.…”

Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor

“…Although kojic acid and arbutin (Figure 1) are applied as tyrosinase inhibitors in the medical and industrial fields, they still have been found to lots of adverse side effects Esma et al, 2023). Now, to find novel tyrosinase inhibitors is essential for treatment of melanin synthesis (Romagnoli et al, 2022;Nasab et al, 2023).…”