These results indicate that (1) more than half the patients who developed hypothyroidism within 6 months after 131I treatment for Graves' disease recovered spontaneously, (2) TSAb activity might play some role in the recovery of transient hypothyroidism, and (3) the development of transient hypothyroidism may influence long-term thyroid function.

An adrerml.spe¢ifie protein reacting with autoantibodi~ in the s:ra of patients with adult onset Addison's dire.am has I:P..¢n purified from human e.drenal 81ands, The protein, real.we. 35K, hits the biochemical characteristi~ of steroid 21.hydroxylase and reacts on W~tern blast with rabbit antibodies to recombinant 21.hydroxylase, Absorption of the native human 55K adrenal protein with human adrenal autoantibodies prevented the subsequent r~ction of the 55K protein with rabbit :-ntibodies to 21-hydroxylase in W~tcrn blot analysis. In addition, human adrenal autoantibodi~ reacted with recombinant 2l-hydroxylas¢ expressed in y~st, These data inditer that the adrenal specific enzyme steroid 21.hydroxyluse is a major uutoanti~n involved in adult on~t autoimmune Addison's dire.ate,

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These results indicate that (1) the TBII index and TSAb activity decreased over a period of more than 2 years after 131I therapy for Graves' disease, and (2) the TBII index before treatment may influence the long-term outcome of 131I therapy.