Autoimmune Addison's disease and 21-hydroxylase

Baumann-Antczak, Aleksandra; Wedlock, D. Neil; Bednarek, Jana M.; Kiso, Yoshinori; Krishnan, Hari B.; Fowler, Susan J.; Smith, Bernard Rees; Furmaniak, Jadwiga

doi:10.1016/0140-6736(92)91513-8

Cited by 72 publications

(25 citation statements)

References 6 publications

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“…It has been found that the adrenal cytochrome p450 enzyme 21 hydroxylase (which converts 17-␣-progesterone and progesterone into 11-deoxy- (191,192), either in the form of isolated adrenal failure or associated with hypothyroidism (type II APGS). In type I APGS it is thought that autoantibodies are directed to other members of the cytochrome p450 enzyme family, namely to the p450 side-chain cleavage enzyme (p450-scc) and to 17-␣-hydroxylase (17-␣-OH) (192)(193)(194)(195)(196), and to an ill-defined 51-kDa protein (197). However, there is some confusion on this subject, and not all investigators could confirm the presence of these autoantibodies in type 1 APGS [negative results: p450-scc (198); 17-␣-OH (198,199)].…”

Section: A Antibodies In Pof Patients With Adrenal Autoimmunity And/mentioning

confidence: 99%

Premature Ovarian Failure and Ovarian Autoimmunity

Hoek¹

1997

Endocrine Reviews

212

221

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Section: A Antibodies In Pof Patients With Adrenal Autoimmunity And/mentioning

confidence: 99%

Premature Ovarian Failure and Ovarian Autoimmunity

Hoek¹

1997

Endocrine Reviews

212

221

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“…This was followed, in 1992, by the identification, independently in two laboratories, of steroid 21-hydroxylase (21-OH) as a major adrenal autoantigen (50)(51)(52). In the same year screening of a human fetal adrenal cDNA library with the sera from patients with AAD in the context of PGAD type 1 allowed isolation of clones with high homology to steroid 17a-hydroxylase (17a-OH) and this study indicated that 17a-OH was an autoantigen associated with the AAD in the context of PGAD type 1 (53).…”

Section: Adrenal Autoantigensmentioning

confidence: 99%

Adrenal and ovarian autoimmunity

Betterle

Volpato²

1998

European Journal of Endocrinology

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“…Adrenal cortex autoantibodies (ACA) are polyclonal immunoglobulins of the IgG class that react with the cytoplasm of adrenal cortex cells (11) and their major specific target autoantigen has been identified to be the steroid 21-hydroxylase (21-OH) (9,12,13). ACA, when present, are markers of clinical, subclinical or potential AD (4,9).…”

Section: Introductionmentioning

confidence: 99%

Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease

Prà

Chen²,

Furmaniak³

et al. 2003

European Journal of Endocrinology

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Design: Adrenal cortex autoantibodies (ACA), steroid-producing cell autoantibodies (StCA) and autoantibodies (Abs) to steroidogenic enzymes in three groups of patients with premature ovarian failure (POF), 15 with autoimmune Addison's disease (AD), 26 with non-adrenal autoimmune diseases and 31 with isolated POF, have been assessed. Methods: ACA and StCA were measured using an immunofluorescence technique. Abs to 21-hydroxylase (21-OH), to 17a-hydroxylase (17a-OH) and to cytochrome P450 side-chain cleavage (P450scc) were measured using an immunoprecipitation assay. Results: Seventy-three percent of patients with POF and AD were positive for StCA, 93% for 17a-OH and/or P450scc Abs, 93% for ACA and 100% for 21-OH Abs. Among patients with POF and nonadrenal autoimmune diseases, 8% were positive for StCA, 12% for 17a-OH and/or P450scc Abs, and 8% and 12% for ACA and 21-OH Abs respectively. StCA, 17a-OH and/or P450scc Abs were all found in 10% of patients with isolated POF, and 13% had ACA and 21-OH Abs. All StCA-, 17a-OH-and/or P450scc Abs-positive patients were also positive for ACA and 21-OH Abs. Two patients with isolated POF who were ACA and 21-OH Ab positive developed AD 3 and 5 years after the onset of POF. Conclusion: This study has shown that, when POF is associated with AD, StCA, 17a-OH and/or P450scc Abs are present in the majority of patients, while in the other two groups these Abs are detectable in a much lower proportion of patients. Measurement of ACA/21-OH Abs in some patients with POF may be important in identifying patients at risk of developing overt AD.

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Autoimmune Addison's disease and 21-hydroxylase

Cited by 72 publications

References 6 publications

Premature Ovarian Failure and Ovarian Autoimmunity

Premature Ovarian Failure and Ovarian Autoimmunity

Adrenal and ovarian autoimmunity

Autoantibodies to steroidogenic enzymes in patients with premature ovarian failure with and without Addison's disease

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