Neutral matrix metalloproteinases (MMPs) play an important role in bone matrix degradation accompanied by bone remodeling. We herein show for the first time that macrophage migration inhibitory factor (MIF) upregulates MMP-13 (collagenase-3) mRNA of rat calvariaderived osteoblasts. The mRNA up-regulation was seen at 3 h in response to MIF (10 g/ml), reached the maximum level at 6 -12 h, and returned to the basal level at
These findings indicate that lutein has anti-inflammatory effects on EIU by inhibiting the NF-kappaB dependent signaling pathway and the subsequent production of proinflammatory mediators.
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