Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo

Shiratori, Kenji; Ohgami, Kazuhiro; Ilieva, Iliyana; Jin, Xin; Koyama, Yoshikazu; Miyashita, Kazuo; Yoshida, Kazuhiko; Kase, Satoru; Ohno, Shigeaki

doi:10.1016/j.exer.2005.03.002

Cited by 190 publications

(111 citation statements)

References 18 publications

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“…Other carotenoids, such as lutein, fucoxanthin, and astaxanthin, also reduce inflammation in EIU (15,(26)(27)(28) . The anti-inflammatory effects of lutein on EIU were attributed to inhibition of NF-kB-dependent signaling (15) , while astaxanthin was suggested to inhibit inflammation via suppression of NO, PGE2, and TNF-α by directly blocking nitric oxide synthase (NOS) activity (26,28) .…”

Section: Histopathology Scoresmentioning

confidence: 99%

“…The identification of new anti-inflammatory compounds is thus required to reduce the complications induced by corticosteroids. Accordingly, numerous clinical and experimental studies have been conducted evaluating nonsteroidal treatment strategies for uveitis (15,(26)(27)(28) . Endotoxin-induced uveitis is a useful model for this purpose.…”

Section: Histopathology Scoresmentioning

confidence: 99%

See 1 more Smart Citation

Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats

Göncü¹,

Oğuz²,

Sezen³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Section: Histopathology Scoresmentioning

confidence: 99%

Section: Histopathology Scoresmentioning

confidence: 99%

Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats

Göncü¹,

Oğuz²,

Sezen³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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“…Our main focus in this study was on carotenoids isolated from H. roretzi, because these possess a similar structure to that of fucoxanthin to exhibit anti-inflammatory effects in vitro and in vivo 21) . To evaluate the anti-inflammatory effects of carotenoids from H. roretzi, their suppressive effects on the expression of pro-inflammatory genes in LPS-stimulated RAW264.7 cells were measured.…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

et al. 2008

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To investigate anti-inflammatory effects of carotenoids from Halocynthia roretzi, gene expression levels were measured for pro-inflammatory cytokines and enzymes in the murine macrophage-like cell line, RAW264.7, stimulated with lipopolysaccharide (LPS). All-trans alloxanthin, all-trans diatoxanthin, and their 9-cis isomers isolated from H. roretzi significantly suppressed expression of IL-1b and IL-6 mRNA in cells induced by LPS without cytotoxicity. The expression level of IL-1b mRNA in cells treated with 25 mM all-trans alloxanthin for 24 h, followed by stimulation with 0.1 mg/mL LPS for 24 h in the presence of carotenoid decreased to 33.7±3.0% from that of control cells stimulated with LPS alone. All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1b mRNA to 25.1±2.1, 28.2±0.9 and 32.9±3.3%, respectively, from that of control cells stimulated with LPS. IL-1b production in culture medium was also suppressed by all-trans alloxanthin and all-trans diatoxanthin. Furthermore, all-trans alloxanthin, all-trans diatoxanthin and their 9-cis isomers suppressed the overexpression of cyclooxygenase-2 and nitric oxide synthase mRNA in RAW264.7 cells induced by LPS. The suppressive effects of these carotenoids were remarkable compared to those of b-carotene and zeaxanthin.

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“…Shiratori et al [35] reported that effect of FUCO is comparable with commercially anti-inflammatory steroidal drug prednisolone. Heo et al [36] screened inhibitory effect of NO production from nine species of brown algae and confirmed that inhibition of NO production correlates with FUCO contents.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Anti-Inflammatory and Anti-Proliferative Effect of Hydroxy-, Keto-, and Epoxy-Carotenoids in RAW 264.7 and HL-60 Cells

Vijay¹,

Sowmya²,

Arathi³

et al. 2016

J Food Chem Nanotechnol

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Aim of the study was to investigate efficiency of hydroxy (lutein, LUT), Keto-(astaxanthin, AST) and epoxy-(fucoxanthin, FUCO) carotenoids on molecular/biochemical events in proliferation of RAW 264.7 and HL-60 cells. Lipopolysaccharide (LPS) induced RAW 264.7 cells treated either with 20 µM of LUT or AST or FUCO or without carotenoid for 12 h, and studied their differential influence on toxicity, inflammatory markers and nuclear factor-κB p65 (NF-κB p65) expression levels. Similarly, HL-60 cells treated for 48 h and evaluated cytotoxicity and apoptosis inducing activity. It was observed, carotenoids treatment decreased cytotoxicity of LPS induced inflammation in macrophages. Among carotenoids, FUCO protects cytotoxicity by 10.7 and 15.8% than AST and LUT, respectively. Likewise, carotenoids treatments reduced Nitric oxide (NO), Prostaglandin E 2 (PGE 2 ) and NF-κB p65 levels than LPS treated group, while FUCO shown to be superior to control markers of inflammation than AST and LUT. Similarly, in case of HL-60 cells, FUCO significantly reduced cell viability by 16.4 and 33.4% than AST and LUT, respectively. Further, increased apoptosis of HL-60 positively correlates with decreased glutathione, and increased malondialdehyde and oxidative stress in cells treated with FUCO than AST and LUT. Also, typical apoptotic morphological changes were observed in FUCO treated cells than other oxygenated carotenoids. These differences among oxygenated carotenoids may be due to functional group and reactivity with the cells. Further, we presumed that an increase in the number of oxygen or hydroxyl groups in the carotenoids may decide the bioactivity. This study provides a greater insight of oxygenated carotenoids to combat chemoprevention of cancers originating from inflammation.

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Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo

Cited by 190 publications

References 18 publications

Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats

Anti-inflammatory effect of lycopene on endotoxin-induced uveitis in rats

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

Evaluation of Anti-Inflammatory and Anti-Proliferative Effect of Hydroxy-, Keto-, and Epoxy-Carotenoids in RAW 264.7 and HL-60 Cells

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