Background This study aimed to compare single-port transumbilical total laparoscopic hysterectomy (SPLS-TLH) and four-port total laparoscopic hysterectomy (TLH) in terms of postoperative pain. Methods The study enrolled 68 patients who underwent TLH
SPLS is a feasible approach for hysterectomy in terms of operative time, complication rates, and cosmetic results. However, the possible benefits for patients such as better cosmetic outcomes, reduced pain, and lower complication rates should be evaluated in randomized prospective studies.
Purpose of review
The lack of effective treatments for various neurodegenerative disorders has placed huge burdens on society. We review the current status application of pluripotent stem cells (iPSCs) technology for the cellular therapy, drug screening and in vitro modeling of neurodegenerative diseases.
Recent findings
Disease specific iPSCs were derived from patients of several major neurodegenerative diseases, including Parkison' disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Differentiation of the SMA-iPSCs into neurons showed the recapitulation of the in vivo phenotypes, allowing us the future use of drug screening. The murine model of Parkinson's transplanted with human iPSCs showed the functional recovery, showing the potential of iPSC as cell therapy. Direct conversion to neurons was succeeded from skin fibroblasts of Alzheimer's patients.
Summary
We summarize the recent progress in using iPSCs for neurodegenerative diseases, and provide a future perspective in this field.
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