Taking aryl propargyl
ether and o-iodibenzoic
acid as substrates, a series of aryl cyclolactones bearing an exocyclized
CC bond were constructed with moderate to good yields. Diverse
substituent groups could be tolerant in the reaction, which indicated
excellent compatibility of the reaction. In this tandem reaction,
Ag2O was employed as the media and Et3N was
screened as the base to facilitate the reaction. A concise mechanism
was proposed on the basis of the expansion of the substrates and theoretical
analysis. Sonogashira type coupling coupled with intramolecular nucleophilic
addition in one pot to construct the product, 3-ethylideneisobenzofuran-1(3H)-one.
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