OBJECTIVEMedical nutrition therapy based on the control of the amount and distribution of carbohydrates (CHO) is the initial treatment for gestational diabetes mellitus (GDM), but there is a need for randomized controlled trials comparing different dietary strategies. The purpose of this study was to test the hypothesis that a low-CHO diet for the treatment of GDM would lead to a lower rate of insulin treatment with similar pregnancy outcomes compared with a control diet.RESEARCH DESIGN AND METHODSA total of 152 women with GDM were included in this open, randomized controlled trial and assigned to follow either a diet with low-CHO content (40% of the total diet energy content as CHO) or a control diet (55% of the total diet energy content as CHO). CHO intake was assessed by 3-day food records. The main pregnancy outcomes were also assessed.RESULTSThe rate of women requiring insulin was not significantly different between the treatment groups (low CHO 54.7% vs. control 54.7%; P = 1). Daily food records confirmed a difference in the amount of CHO consumed between the groups (P = 0.0001). No differences were found in the obstetric and perinatal outcomes between the treatment groups.CONCLUSIONSTreatment of women with GDM using a low-CHO diet did not reduce the number of women needing insulin and produced similar pregnancy outcomes. In GDM, CHO amount (40 vs. 55% of calories) did not influence insulin need or pregnancy outcomes.
Core Genome Multilocus Sequence Typing (cgMLST) and the in vitro resistance and therapeutic failure concordance was evaluated by the Kappa coefficient.Results: We found that the H. pylori resistance prevalence to amoxicillin pbpA SNPs association was 19%, having as frequent mutations, Thr556/Ser, Arg649/Lys y Arg656/Pro. The prevalence of tetracycline resistance was 6% in the 16S rRNA, with A926T, A926G and A928C being the more frequent mutations found. Clarithromycin resistance prevalence was 1.5% in 23S gene where we found the A2142G mutation.Conclusions: The H. pylori resistance SNPs prevalence to amoxicillin was 19%, to tetracycline 6% and clarithromycin 1.5% in the high gastric cancer risk Colombian population. These findings showed that these mutations were associated with therapeutic failure with first-line treatment used for H. pylori eradication in Colombia. In future studies, the combination of WGS analysis and phenotypic associations could help to clearly understand the bacterial resistance to different antibiotics used for H. pylori management in Colombia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.