P-266 Oncological outcomes of self-expanding metal stent as a bridge to surgery for obstructive left-sided colon cancer

Abstract

Core Genome Multilocus Sequence Typing (cgMLST) and the in vitro resistance and therapeutic failure concordance was evaluated by the Kappa coefficient.Results: We found that the H. pylori resistance prevalence to amoxicillin pbpA SNPs association was 19%, having as frequent mutations, Thr556/Ser, Arg649/Lys y Arg656/Pro. The prevalence of tetracycline resistance was 6% in the 16S rRNA, with A926T, A926G and A928C being the more frequent mutations found. Clarithromycin resistance prevalence was 1.5% in 23S gene where we found the A2142G mutation.Conclusions: The H. pylori resistance SNPs prevalence to amoxicillin was 19%, to tetracycline 6% and clarithromycin 1.5% in the high gastric cancer risk Colombian population. These findings showed that these mutations were associated with therapeutic failure with first-line treatment used for H. pylori eradication in Colombia. In future studies, the combination of WGS analysis and phenotypic associations could help to clearly understand the bacterial resistance to different antibiotics used for H. pylori management in Colombia.