Self-assemblies of bioactively natural compounds into supramolecular hydrogels without structural modifications are of interest to improve their sustained releases and bioavailabilities in vivo. However, it is still a formidable challenge to dig out such a naturally small molecule with a meticulous structure which can be self-assembled to form a hydrogel for biomedical applications. Here, a new hydrogel consisting only of gallic acid (GA) via đ -đ stacking and hydrogen bond interactions, whereas none of GA analogues can form the similar supramolecular hydrogels, is reported. This interesting phenomenon is intriguing to further investigate the potential applications of GA hydrogels in wound healing. Notably, this GA hydrogel has rod-like structures with lengths varying from 10 to 100 ÎŒm. The biocompatibility and antibacterial tests prove that this well-assembled GA hydrogel has no cytotoxicity and excellent antibacterial activities against Escherichia coli and Staphylococcus aureus. Moreover, the GA hydrogel can significantly accelerate the process of wound healing with or without bacterial infections by mediation of inflammation signaling pathways. It is believed that the current study may shed a new light on the design of a supramolecular hydrogel based on self-assemblies of naturally small molecules to improve their bioavailabilities and diversify their uses in biomedical applications.
The emission of Greenhouse gases (GHG) during the life cycle of four hydropower stations with installed capacity from 95 MW to 500 MW are assessed by the integrated GHG reservoir tool developed by International Hydropower Association. Model inputs are extracted from multi-source geographic datasets and construction planning documents. Three main conclusions are summarized: (1) In pre-and post-impoundment stages, areal GHG emission balance in reservoir area depends on the climate background, humid subtropical regions are more active than arid temperate regions. In the construction stage, emissions from fill, concrete and equipment account for more than 70% of the total. (2) GHG intensity falls rapidly when lifetime increases from 10 to 40 years and then drops slightly when lifetime becomes longer, which is 13.60 tCO 2 e/GWh for 50 years and 8.13 tCO 2 e/GWh for 100 years on average. The emission rates of hydropower stations with lower installed capacity are obviously large if they work for less than 30 years and differ less with stations possessing a higher installed capacity when their lifetime approaches 100 years. (3) Comparing with electricity generated by coal in China whose GHG intensity is 822 tCO 2 e/GWh, hydroelectricity is almost 100 times more efficient and clean. Thus, hydropower station plays an important role in dealing with the global warming issue as a substitution for a fossil fuel power source.
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