Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing

Hou, Yiyang; Huang, Haibo; Gong, Wei; Wang, Ran; He, Wanying; Wang, Xinchuang; Hu, Jiang‐Ning

doi:10.1016/j.bioadv.2022.213034

Cited by 15 publications

(11 citation statements)

References 48 publications

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“…After ultrasonic treatment and cooling to room temperature, the mixed solution spontaneously formed the GAS hydrogel. The GA hydrogel was obtained according to our previous reports. ,, …”

Section: Methodsmentioning

confidence: 99%

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Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis

Huang

Gong

Hou

et al. 2023

J. Agric. Food Chem.

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Mucoadhesive hydrogels with multifunctional properties such as gastric acid resistance and sustained drug release in the intestinal tract are highly desirable for the oral treatment of inflammatory bowel diseases (IBDs). Polyphenols are proven to have great efficacies compared with the first-line drugs for IBD treatments. We recently reported that gallic acid (GA) was capable of forming a hydrogel. However, this hydrogel is prone to easy degradation and poor adhesion in vivo. To tackle this problem, the current study introduced sodium alginate (SA) to form a gallic acid/sodium alginate hybrid hydrogel (GAS). As expected, the GAS hydrogel showed excellent antiacid, mucoadhesive, and sustained degradation properties in the intestinal tract. In vitro studies demonstrated that the GAS hydrogel significantly alleviated ulcerative colitis (UC) in mice. The colonic length of the GAS group (7.75 ± 0.38 cm) was significantly longer than that of the UC group (6.12 ± 0.25 cm). The disease activity index (DAI) value of the UC group was (5.5 ± 0.57), which was markedly higher than that of the GAS group (2.5 ± 0.65). The GAS hydrogel also could inhibit the expression of inflammatory cytokines, regulating macrophage polarization and improving the intestinal mucosal barrier functions. All these results indicated that the GAS hydrogel was an ideal candidate for oral treatment of UC.

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“…After ultrasonic treatment and cooling to room temperature, the mixed solution spontaneously formed the GAS hydrogel. The GA hydrogel was obtained according to our previous reports. ,, …”

Section: Methodsmentioning

confidence: 99%

“…The GA hydrogel was obtained according to our previous reports. 40,41,46 Characterization of the GAS Hydrogel. The microstructure of the GAS hydrogel was observed using cold field emission scanning electron microscopy (cryo-SEM, SU8010/PP3010T, Japan).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis

Huang

Gong

Hou

et al. 2023

J. Agric. Food Chem.

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“…The composite hydrogel was further applied to diabetic wounds, which resulted in a considerable re-epithelization of the lesions and on-site collagen aggregation. In addition, an immunofluorescent study supported a diminution of inflammatory markers and COX-2 levels in the recovering injury [ 169 ]. A synthesized caffeic acid-loaded nanoliposomal vesicle formed of sodium deoxycholate (SDC) was developed for attenuating pancreatitis.…”

Section: Designed Polyphenolic-loaded Nanocarriers For Inflammation-m...mentioning

confidence: 99%

Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

2023

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The global increase and prevalence of inflammatory-mediated diseases have been a great menace to human welfare. Several works have demonstrated the anti-inflammatory potentials of natural polyphenolic compounds, including flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids (GA, CA, etc.), among others (resveratrol, curcumin, etc.). In order to improve the stability and bioavailability of these natural polyphenolic compounds, their recent loading applications in both organic (liposomes, micelles, dendrimers, etc.) and inorganic (mesoporous silica, heavy metals, etc.) nanocarrier technologies are being employed. A great number of studies have highlighted that, apart from improving their stability and bioavailability, nanocarrier systems also enhance their target delivery, while reducing drug toxicity and adverse effects. This review article, therefore, covers the recent advances in the drug delivery of anti-inflammatory agents loaded with natural polyphenolics by the application of both organic and inorganic nanocarriers. Even though nanocarrier technology offers a variety of possible anti-inflammatory advantages to naturally occurring polyphenols, the complexes’ inherent properties and mechanisms of action have not yet been fully investigated. Thus, expanding the quest on novel natural polyphenolic-loaded delivery systems, together with the optimization of complexes’ activity toward inflammation, will be a new direction of future efforts.

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“…In China, medicinal food homologous (MFH) refers to the concept that some foods can be used as medicine, and there is no clear boundary between them (see Figure S1) (Hou et al., 2022). Many foods can be used both as a part of a regular diet and as a form of medicine to prevent or treat diseases (Zhai et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The research on the network pharmacology of traditional Chinese medicine aims to unveil the mysteries of traditional Chinese medicine formulas at the molecular and systematic levels. This promotes a shift in traditional Chinese medicine research from the current “single target, single drug” model to a new model of “network target, multi‐component drugs.” Currently, individual components, such as sour jujube kernels, ginseng, and cypress kernels have been studied for their therapeutic effects on insomnia (Hou et al., 2022). However, most studies tend to focus on the effects of a single drug on insomnia, and little is known about the collection of important components that contribute to the efficacy of numerous drugs in treating insomnia.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and experiment indicated that medicinal food homologous components play important roles in insomnia

Xu,

Liu,

et al. 2023

Food Frontiers

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Insomnia refers to a subjective experience where insufficient sleep duration and quality affect daytime social functioning. This study aims to screen bioactive components with medicinal food homologous (MFH), such as quercetin, beta‐sitosterol, kaempferol, stigmasterol, and capsaicin, which can treat insomnia and demonstrate that quercetin acts as a direct inhibitor of insomnia‐related glucosylceramidase and as an insulin receptor tyrosine phosphatase inhibitor in the upstream insulin signaling pathway, affecting insomnia targets in the downstream pathway for the treatment of insomnia, using network pharmacology and cell experiment approaches. The results showed that 703 components in 44 MFH were enriched in 139 metabolic pathways and acted on 210 potential targets of insomnia. The protein–protein interaction network is analyzed by cytoNCA, according to the topological analysis results, quercetin, beta‐sitosterol, kaempferol, stigmasterol, and capsaicin of betweenness ranked in the top 10. Quercetin and glucosylceramidase were shown to directly inhibit insomnia proteins through reverse molecular docking. Quercetin was used to culture and stimulate HepG2 cells to detect tyrosine phosphorylation of key cellular proteins in the insulin signaling pathway, concluding that quercetin inhibits the activity of tyrosine phosphatase in a dose‐dependent manner, activating the insulin signaling pathway, triggering a cascade reaction, and affecting the expression of insomnia targets in the downstream pathway. The molecular docking of tyrosine phosphatase and quercetin revealed that quercetin interacted with it near the catalytic site, thereby inhibiting its interaction with the substrate. Overall, this study facilitates the development of medicinal food homologous, which exerts good pharmacological effects in the treatment of insomnia.

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Co-assembling of natural drug-food homologous molecule into composite hydrogel for accelerating diabetic wound healing

Cited by 15 publications

References 48 publications

Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis

Mucoadhesive Hydrogel with Anti-gastric Acid and Sustained-Release Functions for Amelioration of DSS-Induced Ulcerative Colitis

Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

Network pharmacology and experiment indicated that medicinal food homologous components play important roles in insomnia

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