Modulating Inflammation-Mediated Diseases via Natural Phenolic Compounds Loaded in Nanocarrier Systems

Abstract

The global increase and prevalence of inflammatory-mediated diseases have been a great menace to human welfare. Several works have demonstrated the anti-inflammatory potentials of natural polyphenolic compounds, including flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids (GA, CA, etc.), among others (resveratrol, curcumin, etc.). In order to improve the stability and bioavailability of these natural polyphenolic compounds, their recent loading applications in both organic (liposomes, micelles, dendrimers, etc.) and inorganic (mesoporous silica, heavy metals, etc.) nanocarrier technologies are being employed. A great number of studies have highlighted that, apart from improving their stability and bioavailability, nanocarrier systems also enhance their target delivery, while reducing drug toxicity and adverse effects. This review article, therefore, covers the recent advances in the drug delivery of anti-inflammatory agents loaded with natural polyphenolics by the application of both organic and inorganic nanocarriers. Even though nanocarrier technology offers a variety of possible anti-inflammatory advantages to naturally occurring polyphenols, the complexes’ inherent properties and mechanisms of action have not yet been fully investigated. Thus, expanding the quest on novel natural polyphenolic-loaded delivery systems, together with the optimization of complexes’ activity toward inflammation, will be a new direction of future efforts.

Protective effect of tomato pomace extract encapsulated in combination with probiotics against indomethacin induced enterocolitis

“…Additionally, polyphenols activate the antioxidant enzymes and reduce oxidative stress and inflammation 51 . The anti-inflammatory effect of flavonoid derivatives (EGCG, rutin, apigenin, naringenin) and phenolic acids was demonstrated by several reports 52 . Probiotics have become more well-liked in recent years as a result of their ability to treat diseases caused by inflammation.…”

Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review

“…Plant extracts and extracted bioactive components have been employed as therapeutic agents for the treatment and prevention of illnesses and afflictions all over the world since ancient times [ 38 , 39 ]. Herbal drugs include any plant-based items used for health maintenance or restoration.…”

“…Drug delivery systems based on nanotechnology have been investigated to see whether they can circumvent these drawbacks [ [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ]. Nanostructured drug delivery devices have superior physicochemical and biological features to their microscale counterparts [ [38] , [39] , [40] , [41] , [42] ]. Optically, the former systems are superior; their surface areas, conductivities, and interactions with biological molecules are enhanced ( Fig.…”

Dendrimers as Nanocarriers for the Delivery of Drugs Obtained from Natural Products

“…Their specificity, low toxicity, or non-toxicity are key advantages of dendrimers as anticancer agents, especially in the field of oncology [ 57 , 58 , 59 , 60 , 61 ]. However, their low bioavailability in humans limits their clinical applications [ 62 , 63 , 64 ].…”