Construction of double network hydrogels using agarose and gallic acid with antibacterial and anti-inflammatory properties for wound healing

Gong, Wei; Wang, Ran; Huang, Haibo; Hou, Yiyang; Wang, Xinchuang; He, Wanying; Gong, Xiaojie; Hu, Jiang‐Ning

doi:10.1016/j.ijbiomac.2022.12.085

Cited by 34 publications

(23 citation statements)

References 54 publications

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“…Enrichment of heme biosynthesis has been reported to promote bacteria in Proteobacteria and in ammation in the gut [43,44]. Gallates have excellent bioactivity for bacterial inhibition and the reduction of in ammation [45]. Our observation of gallate degradation in AG_P suggests that a reduction in gallate levels in the stomach may induce an increase in AG_P-related microbes.…”

Section: Discussionmentioning

confidence: 60%

A Meta-analysis Reveals Gastric Microbes Associated with Atrophic Gastritis

Gao

Yin

Ren

et al. 2023

Preprint

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Previous studies have associated microbial alterations with gastritis; however, problems regarding the reproducibility of biomarkers in cohorts remain poorly resolved. Patients from different regions provided excellent information, that was conducive to the exploration of the gastric microbes associated with gastric inflammation. We performed a meta-analysis of seven reliable datasets, consisting of a total of 367 fecal 16s rRNA including atrophic gastritis (AG) (174 patients) and superficial gastritis (SG) (170 patients) after quality control and discarding samples of gastric fluid, since the microbial diversity between gastric fluid and antrum was different. We also investigated the similarity in microbial composition between healthy controls and SG without Helicobacter pylori infection, but not in those with H. pylori infection. According to the linear discriminant analysis effect size and random forest analyses, Bacteroides, Weissella, Actinomyces, Atopobium, Oribacterium, Peptostreptococcus, and Rothia were biomarkers between SG and AG (AG_N) without H. pylori infection, whereas Actinomyces, Cutibacterium, Helicobacter, Novosphingobium, Pseudomonas, and Streptococcus were signatures between SG and AG (AG_P) with H. pylori infection. We also found that the development of AG_N was associated with lower vitamin B12 levels, whereas significant changes in the gastric microbiota functions of AG_P included gallate, amino acid degradation, and heme biosynthesis. In addition, non-dialysis classifiers were developed for AG_N with an area under the curve (AUC) of 0.7417 and for AG_P with an AUC of 0.8862. This study thoroughly profiled the gastric microbiota of AG and SG and provided evidence of the potential of microbial markers as noninvasive classifiers for global AG.

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Section: Discussionmentioning

confidence: 60%

A Meta-analysis Reveals Gastric Microbes Associated with Atrophic Gastritis

Gao

Yin

Ren

et al. 2023

Preprint

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“…Swelling behavior is an important property of hydrogels and is usually measured by a gravimetric method. 47 In this paper, the swelling ratio of the F 5 −Pep hydrogel was measured at pH 8.5, 7.4, and 6.0. All of the hydrogels (2.0 wt %, pH 6.0, 400 μL) were weighed after their preparation (W a ).…”

Section: Swelling Studiesmentioning

confidence: 99%

“…Swelling behavior is an important property of hydrogels and is usually measured by a gravimetric method . In this paper, the swelling ratio of the F 5 –Pep hydrogel was measured at pH 8.5, 7.4, and 6.0.…”

Section: Experimental Sectionmentioning

confidence: 99%

Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

Mei,

Yang,

Dong

et al. 2024

ACS Appl. Nano Mater.

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The abnormal levels of pH and oxygen (O 2 ) in the wound microenvironment impeded wound healing, and their regulation remains a challenge. Thus, a wound dressing with pH and O 2 -regulating capacity is urgently desired. Here, we designed and prepared a fluorinated peptide hydrogel wound dressing to regulate the pH and O 2 microenvironment of the wound site. Fluorinated peptides with the (naphthalene-2-ly)-Gly-5f Phe-5f Phe-Tyr-Arg-Gly-Asp sequence (F 5 −Pep) could self-assemble to a nanofiber network in a weak acidic buffer (pH = 6.0), which is similar to the pH of human skin. The F 5 −Pep hydrogel can maintain pH levels at 6.0−7.3 for 24 h and continuously release O 2 for 4 h. The blood coagulation and hemostasis assay showed that the F 5 −Pep hydrogel significantly accelerated blood clotting speed in vitro and rapidly controlled hemorrhage in a mouse liver hemorrhage model. In vitro cell migration assays and in vivo animal experiments confirmed that the F 5 −Pep hydrogel can promote cell migration and wound healing. In summary, this work might provide an effective treatment strategy for wounds and develop advanced wound-healing materials.

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“…Behera et al [ 253 ] reported that gallic acid reveals antioxidant or free radical scavengers in adipocyte proliferation. Gallic acid is found in a wide range of natural plants, it is associated with the health of human beings, and it has well-documented anticancer, antibacterial, anti-inflammatory, and antifungal activities [ 254 , 255 ]. Gallic acid in Emblica officinalis mediated antidiabetic potential and delineated the upregulation of pAkt, PPAR-γ, and Glut4 through gallic acid-mediated antidiabetic properties, thus providing potent therapy for diabetes [ 256 ].…”

Section: Hydroxybenzoic Acids (Gallic Acid and Protocatechuic Acid)mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Construction of double network hydrogels using agarose and gallic acid with antibacterial and anti-inflammatory properties for wound healing

Cited by 34 publications

References 54 publications

A Meta-analysis Reveals Gastric Microbes Associated with Atrophic Gastritis

A Meta-analysis Reveals Gastric Microbes Associated with Atrophic Gastritis

Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

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