No abstract

Little is known about whether diet quality is associated with thyroid function. We aimed to examine the relationship between diet quality and thyroid function. Data were from the National Health and Nutrition Examination Surveys, 2007–2012. A total of 3603 males who were at least 20 years old and had dietary recall data were included in the analysis. Thyroid function was assessed by eight indexes, including total and thyroglobulin antibodies, thyroid peroxidase antibodies, free T4 and T3, total T4 and T3, Tg, and thyroid‐stimulating hormone. Multivariable linear regression, subgroup analyses, and interaction terms were employed to test the association between healthy eating index (HEI) and thyroid function. A total of 3603 male participants aged ≥20 years with an average age of 48.17 ± 0.51 years were enrolled. We found a negative association between HEI‐2010 and total T3 (β = −3.41; p = .01) and free T3 (β = −0.06; p = .01). In subgroup analyses, HEI‐2010 was negatively associated with TT3 in male participants aged <65 years old (β = −4.57; p < .01) and FT3 (β = −0.09; p < .001). Higher HEI‐2010 was inversely associated with lower total T3 and free T3. More well‐designed studies are still needed to validate the causal relationship between HEI and thyroid function.

Background: The impact of the potential inflammatory effect of diet on hyperuricemia has not been adequately investigated. The aim of our study was to evaluate the association of Dietary Inflammatory Index (DII) on hyperuricemia in American adults.Methods: We conducted a cross-section study using the public database of the National Health and Nutrition Examination Survey (NHANES), 2007-2016. The dietary inflammatory index (DII) score was based on dietary recall interviews. The relationship between DII score and hyperuricemia was evaluated by multivariable adjusted logistic regression models and stratification analyses by potential confounders.Results: A total of 18,282 participants were eligible for this study. Multivariable logistic regression models suggested that hyperuricemia is independently correlated with DII scores. Compared to the lowest quartile of DII scores, the odds ratio (OR) for participants in the third and fourth quartile were 1.50 (95%CI: 1.26-2.78), 1.45 (95%CI: 1.25-1.68) for hyperuricemia (P-trend < 0.0001). Subgroup analysis showed that the association between the dietary inflammatory index and hyperuricemia was statistically significant in age groups, sex groups, white and black race, overweight subjects, marital status groups, PIR groups, none and ex-smokers, diabetes groups and hypertension groups.Conclusion: The results provide evidence of a positive association between DII score and hyperuricemia in American adults.