The association between Dietary Inflammatory Index and hyperuricemia: NHANES 2007–2016

Abstract

Background: The impact of the potential inflammatory effect of diet on hyperuricemia has not been adequately investigated. The aim of our study was to evaluate the association of Dietary Inflammatory Index (DII) on hyperuricemia in American adults.Methods: We conducted a cross-section study using the public database of the National Health and Nutrition Examination Survey (NHANES), 2007-2016. The dietary inflammatory index (DII) score was based on dietary recall interviews. The relationship between DII score and hyperuricemia was evaluated by multivariable adjusted logistic regression models and stratification analyses by potential confounders.Results: A total of 18,282 participants were eligible for this study. Multivariable logistic regression models suggested that hyperuricemia is independently correlated with DII scores. Compared to the lowest quartile of DII scores, the odds ratio (OR) for participants in the third and fourth quartile were 1.50 (95%CI: 1.26-2.78), 1.45 (95%CI: 1.25-1.68) for hyperuricemia (P-trend < 0.0001). Subgroup analysis showed that the association between the dietary inflammatory index and hyperuricemia was statistically significant in age groups, sex groups, white and black race, overweight subjects, marital status groups, PIR groups, none and ex-smokers, diabetes groups and hypertension groups.Conclusion: The results provide evidence of a positive association between DII score and hyperuricemia in American adults.