LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1

Han, Ting; Gao, Mingbo; Wang, Xin; Li, Wei; Zhuo, Jialu; Qu, Zhihua; Chen, Yiqiu

doi:10.1016/j.yexmp.2021.104639

Cited by 10 publications

(10 citation statements)

References 26 publications

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“…Functionally, the silencing of LINC00665 can inhibit the growth, migration and invasion of CRC cells in vitro, and at the same time stimulate cell apoptosis. In mechanism, LINC00665 sponge miR-214-3p up-regulates the expression of CTNNB1, thereby activating the Wnt/β-catenin signaling pathway [ 118 ]. tRF3008A destabilizes FOXK1 in an ago-dependent manner, thereby inhibiting colorectal cancer progression and metastasis [ 119 ].…”

Section: Wnt Pathway-related Biochemical Processmentioning

confidence: 99%

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

et al. 2022

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Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults. The canonical Wnt signaling pathway regulates cell pluripotency and determines the differentiation fate of cells during development. The canonical Wnt signaling pathway (also known as the Wnt/β-catenin signaling pathway) is a recognized driver of colon cancer and one of the most representative signaling pathways. As a functional effector molecule of Wnt signaling, the modification and degradation of β-catenin are key events in the Wnt signaling pathway and the development and progression of colon cancer. Therefore, the Wnt signaling pathway plays an important role in the pathogenesis of diseases, especially the pathogenesis of colorectal cancer (CRC). Objective Inhibit the Wnt signaling pathway to explore the therapeutic targets of colorectal cancer. Methods Based on studying the Wnt pathway, master the biochemical processes related to the Wnt pathway, and analyze the relevant targets when drugs or inhibitors act on the Wnt pathway, to clarify the medication ideas of drugs or inhibitors for the treatment of diseases, especially colorectal cancer. Results Wnt signaling pathways include: Wnt/β-catenin or canonical Wnt signaling pathway, planar cell polarity (Wnt-PCP) pathway and Wnt-Ca2+ signaling pathway. The Wnt signaling pathway is closely related to cancer cell proliferation, stemness, apoptosis, autophagy, metabolism, inflammation and immunization, microenvironment, resistance, ion channel, heterogeneity, EMT/migration/invasion/metastasis. Drugs/phytochemicals and molecular preparations for the Wnt pathway of CRC treatment have now been developed. Wnt inhibitors are also commonly used clinically for the treatment of CRC. Conclusion The development of drugs/phytochemicals and molecular inhibitors targeting the Wnt pathway can effectively treat colorectal cancer clinically.

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Section: Wnt Pathway-related Biochemical Processmentioning

confidence: 99%

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

et al. 2022

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“…A study by Han et al. ( 31 ) also found that LINC00665 was abnormally upregulated in CRC cells and mainly located in the cytoplasm of HCT-116 and SW480 cells. Molecular investigations found that LINC00665 could increase the expression of CTNNB1 by sponging miR-214-3p or binding to U2AF2 protein, further activating the Wnt/β-catenin signaling pathway to promote the tumorigenesis of CRC.…”

Section: Linc00665 Dysregulation and Biological Roles In Human Cancersmentioning

confidence: 88%

The Biological and Molecular Function of LINC00665 in Human Cancers

Zhang

et al. 2022

Front. Oncol.

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Long non-coding RNAs (lncRNAs) are more than 200 nucleotides in length and are implicated in the development of human cancers, without protein-coding function. Mounting evidence indicates that cancer initiation and progression are triggered by lncRNA dysregulation. Recently, a growing number of studies have found that LINC00665, a long intergenic non-protein coding RNA, may be associated with various cancers, including gastrointestinal tumors, gynecological tumors, and respiratory neoplasms. LINC00665 was reported to be significantly dysregulated in cancers and has an important clinical association. It participates in cell proliferation, migration, invasion, and apoptosis through different biological pathways. In this review, we summarize the current findings on LINC00665, including its biological roles and molecular mechanisms in various cancers. LINC00665 may be a potential prognostic biomarker and novel therapeutic target for cancers.

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“…Another study found that LINC00665 could upregulate the expression of PAK2 and FZD3 through sponging miR-126-5p (Wu et al, 2021). Han et al (2021) found that LINC00665 could activate the Wnt/β-catenin signaling pathway by upregulating the expression of CTNNB1, ultimately stimulating the tumorigenicity of colorectal cancer. When they explored the mechanism of LINC00665 regulating CTNNB1, they found that LINC00665 could upregulate the expression level of CTNNB1 through sponging miR-214-3p or by binding to U2AF2 protein to enhance the stability of CTNNB1 mRNA (Han et al, 2021).…”

Section: Colorectal Cancermentioning

confidence: 99%

“…They found that the high expression of LINC00665 in tumor tissues was significantly related to regional lymph node metastasis and poor colorectal cancer tissue differentiation in patients. Experiments in vitro revealed that LINC00665 knockdown could inhibit the proliferation, migration, and invasion of colorectal cancer cells and induce apoptosis in colorectal cancer cells ( Zhao et al, 2020c ; Han et al, 2021 ; Wu et al, 2021 ). Mechanistically, researchers used StarBase to predict the targeted miRNA of LINC00665 and found that miR-9-5p was one of the candidate targets of LINC00665 ( Zhao et al, 2020c ).…”

Section: Function Of Linc00665 In Cancers and Underlying Molecular Me...mentioning

confidence: 99%

“…Existing studies have revealed that lncRNAs are involved in a variety of biological processes, including tumor cell proliferation (Wang et al, 2020a), apoptosis (Zhao et al, 2020a), epithelial to mesenchymal transition (EMT) (McCabe and Rasmussen, 2021), migration (Dhamija and Diederichs, 2016), invasion (Dhamija and Diederichs, 2016), drug resistance (Wei et al, 2020), angiogenesis (Zhao et al, 2020b), and metabolism (Lin, 2020). Although many studies have revealed the expression level and function Hepatocellular carcinoma oncogene upregulated proliferation, migration, invasion, apoptosis, autophagy, glycolysis miR-186-5p/MAP4K3; miR-214-3p/ MAPK1, NF-κB/LINC00665/PKR/ NF-κB Wen et al (2018), Shan and Li (2019), Ding et al (2020), Wan et al (2021) Colorectal cancer oncogene upregulated proliferation, migration, invasion, apoptosis, cell cycle miR-9-5p/ATF1; miR-126-5p/PAK2, FZD3, miR-214-3p, U2AF2/ CTNNB1/Wnt/β-catenin (Zhao et al, 2020c;Han et al, 2021;Wu et al, 2021) Ovarian cancer oncogene upregulated proliferation, migration, invasion, autophagy miR-34a-5p/E2F3; miR-146a-5p/ CXCR4 of lncRNAs in human cancers, the detailed regulatory mechanisms of many lncRNAs in the occurrence and progression of human cancers are still unknown. LINC00665 (also called CIP2A-BP) is a novel lncRNA located on chromosome 19q13.12 and abnormally expressed in many cancers (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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The Emerging Roles of LINC00665 in Human Cancers

Zhu

Zhang

Chen

et al. 2022

Front. Cell Dev. Biol.

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Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides and can participate in the regulation of gene expression in various ways. An increasing number of studies have shown that the dysregulated expression of lncRNAs is related to the occurrence and progression of human cancers. LINC00665 is a novel lncRNA, which is abnormally expressed in various human cancers, such as lung cancer, breast cancer, prostate cancer, and glioma. LINC00665 functions in many biological processes of tumor cells, such as cell proliferation, migration, invasion, angiogenesis, and metabolism, and is related to the clinicopathological characteristics of cancer patients. LINC00665 can play biological functions as a ceRNA, directly binding and interacting with proteins, and as an upstream molecule regulating multiple signaling pathways. In this review, we comprehensively summarize the expression level, function, and molecular mechanisms of LINC00665 in different human cancers and emphasize that LINC00665 is a promising new diagnostic, prognostic biomarker, and therapeutic target.

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LINC00665 activates Wnt/β-catenin signaling pathway to facilitate tumor progression of colorectal cancer via upregulating CTNNB1

Cited by 10 publications

References 26 publications

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

The Biological and Molecular Function of LINC00665 in Human Cancers

The Emerging Roles of LINC00665 in Human Cancers

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