The Taiwan MDR-TB Consortium operates under a strong collaboration between the public health authority and clinical teams. It has achieved a high treatment success rate and low loss to follow-up rate in the management of multidrug-resistant tuberculosis.
Coronary heart disease (CHD) is one of the main causes of death worldwide. In the past few decades, several in-depth research on the pathological mechanisms and effective treatment methods for CHD have been conducted. At present, the intervention of a variety of therapeutic drugs and treatment technologies have greatly reduced the burden on global public health. However, severe arrhythmia and myocardial fibrosis accompanying CHD in the later stages need to be addressed urgently. Mitochondria are important structural components for energy production and the main sites for aerobic respiration in cells. Mitochondria are involved in arrhythmia, myocardial fibrosis, and acute CHD and play a crucial role in regulating myocardial ischemia/hypoxia. Mitochondrial dysfunction or mitophagy disorders (including receptor-dependent mitophagy and receptor-independent mitophagy) play an important role in the pathogenesis of CHD, especially mitophagy. Mitophagy acts as a “mediator” in the inflammatory damage of cardiomyocytes or vascular endothelial cells and can clear mitochondria or organelles damaged by inflammation under normal conditions. We reviewed experimental advances providing evidence that mitochondrial homeostasis or mitochondrial quality control are important in the pathological mechanism of CHD. Further, we reviewed and summarized relevant regulatory drugs that target mitochondrial function and quality control.
Objective: To evaluate effects of Shendi Tang Maining Decoction on steatosis of hepatocyte in type 2 diabetes mellitus. Methods: Type 2 diabetes was induced, in female Wistar rats, by intraperitoneal injection of streptozotocin (25 mg/kg BW), fed with high sucrose and high lipid food. Animals were divided into 2 groups, type 2 diabetes control group (T2DMC group; n=12), type 2 diabetes invention group (T2DMI group; n=12). The age and sex matched Wistar rats served as normal control group (NC group, n=12). The rats of T2DMI group were fed with Shendi Tang Maining Decoction [active pharmaceutical ingredient 5mg/(kg BW•d)]. The rat of NC group and T2DMC were fed with cool boiled water. Results: Steatosis of hepatocyte was significant more in every group of type 2 diabetes than NC group (P<0.01). Steatosis of hepatocyte was significant less in T2DNI group than T2DMC group (P<0.01). Hepatic PAS stain was significant lighter in every group of type 2 diabetes than NC group (P<0.01). Hepatic PAS stain was significant darker in T2DNI group than T2DMC group(P<0.01). Conclusion: Shendi Tang Maining Decoction can ameliorate steatosis and glycogen quantity of hepatocyte in type 2 diabetes mellitus.
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