Increased resistin may suppress reactive oxygen species production and inflammasome activation in type 2 diabetic patients with pulmonary tuberculosis infection

Wen, Chuangyu; Yen, Chia Liang; Wu, Ying; Chen, Shin Yi; Hsieh, Ching Lin; Chang, Tsung Chain; Ou, Horng Yih; Shieh, Chi Chang

doi:10.1016/j.micinf.2014.11.009

Cited by 55 publications

(41 citation statements)

References 43 publications

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“…In addition, neutrophils produce higher levels of oxidative species in GD patients than controls [41]. However, it has been reported that resistin decreased oxidative burst in neutrophils [42, 43]. From our data, we demonstrated that supplemented with T3, the neutrophils could produced less amount of resistin, so that the suppressive effect of resistin on ROSs production might be crippled, resulting in a robust synthesis of detrimental ROSs after compensating for the reduction of neutrophils.…”

Section: Discussionmentioning

confidence: 63%

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Peng

Huang

et al. 2016

Oncotarget

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Resistin, belongs to cysteine-rich secretory protein, is mainly produced by circulating leukocytes, such as neutrophils monocytes and macrophages in humans. To date, few but controversial studies have reported about resistin concentrations in hyperthyroid patients, especially in Graves' disease (GD). We undertaked a controlled, prospective study to explore the serum resistin concentration in GD patients before and after -MMI treatment. In addition, we also investigated the main influencing factor on serum resistin level and discuessed the potential role of serum resistin plays in GD patients. 39 untreated GD (uGD) patients, including 8 males and 31 females, were enrolled in our investigation. All of these patients were prescribed with MMI treatment, in addition to 25 healthy controls. Anthropometric parameters and hormone assessment were measured. Enzyme-linked immunosorbent assay was used to detect serum resistin concentration in different stages of GD patients. Furthermore, neutrophil cell line NB4 with or without T3 treatment to detect the effect of thyroid hormones on resistin expression. The serum resistin level and neutrophil counts in untreated GD patients were significantly declined. And all of these parameters were recovered to normal after MMI treatment in ethyroid GD (eGD) and TRAb-negative conversion (nGD) patients. Resistin concentration exhibited a negative correlation with FT3 and FT4, but a positive correlation with absolute number of neutrophiles in uGD patients, whereas did not correlate with thyroid autoimmune antibodies and BMI. Neutrophile cell line, NB4, produced decreased expression of resistin when stimulated with T3. Our study showed a decrease of serum resistin level in GD patients and we suggested that the serum resistin might primarily secreted from circulating neutrophils and down-regulated by excessive thyroid hormones in GD patients.

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Section: Discussionmentioning

confidence: 63%

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Peng

Huang

et al. 2016

Oncotarget

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“…Neutrophils from diabetic patients showed increased production of inflammatory cytokines [80] and ROS without any stimulation, although neutrophil oxidative responses to certain pathogens appear to be predominantly suppressed in diabetes [64,81,82]. Furthermore, hyperglycemia led to decreased mRNA synthesis of different pro-inflammatory cytokines in neutrophils after LPS stimulation, compared with the euglycemic state [55].…”

Section: Neutrophil Response To Bacterial Infections In Diabetesmentioning

confidence: 99%

Neutrophil Function Impairment Is a Host Susceptibility Factor to Bacterial Infection in Diabetes

Insuela¹,

Coutinho²,

Martins³

et al. 2020

Cells of the Immune System

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Diabetes mellitus is a highly prevalent noncommunicable disease globally. One of the main complications of diabetes is the increased susceptibility to bacterial infection. Neutrophils play a crucial role in inflammatory response against bacterial infections, once they are the first cells recruited to the sites of injury. In diabetes, there is a failure in the neutrophil functions, including migration, ROS production, phagocytosis, and bacterial killing, which are associated with the high incidence of bacterial infections. Herein, we point out pieces of evidence revealing the primary molecular mechanisms involved with impairment of neutrophil functions in diabetes, with relationship with high susceptibility to bacterial infections.

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“…Moreover, patient suffering from DM was found to have inhibited level of MTB antigen specific cytokines (type 1 and type 17) [41]. Elevation in resistin level, a protein produced by immune cells in humans, diminishes the activation of mycobacterium-induced inflammasome through suppressing ROS production in leukocytes [42]. In some studies Vitamin D is proposed as an adjuvant for MTB treatment.…”

Section: Dm Enhances Susceptibility To Tb Infectionmentioning

confidence: 99%

Diabetes Mellitus as Hub for Tuberculosis Infection: A Snapshot

Pal

Ansari

Hameed

et al. 2016

International Journal of Chronic Diseases

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Tuberculosis (TB) still remains the thorn in the flesh of efficient therapeutics affecting one-third of global population annually. There are several factors that enhance the susceptibility to TB infections including malnutrition, smoking, and immunocompromised conditions such as AIDS. In the recent years, growing body of evidence has gained considerable prominence which suggests that Diabetes Mellitus (DM) is individual risk factor leading to complicated TB infections. In this article the authors have attempted to summarize the link of type 2 DM with TB, the mechanistic action of how DM sensitizes for developing the active TB infection from the latent infection, and problems faced during treatment followed by possible preventive measures. We have tried to give account of the alterations that occurred in DM making a person more prone to develop TB.

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Increased resistin may suppress reactive oxygen species production and inflammasome activation in type 2 diabetic patients with pulmonary tuberculosis infection

Cited by 55 publications

References 43 publications

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Down-regulated resistin level in consequence of decreased neutrophil counts in untreated Grave's disease

Neutrophil Function Impairment Is a Host Susceptibility Factor to Bacterial Infection in Diabetes

Diabetes Mellitus as Hub for Tuberculosis Infection: A Snapshot

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