The effervescent tablet containing extract of temulawak (Curcuma xanthorrhiza Roxb.) with variation of stevia sweetener has been formulated using wet granulation method. This research aims to find the formulation of effervescent tablet of temulawak extract (Curcuma xanthorrhiza Roxb.) with the variation of stevia sweetener that meets the requirements of physical tablet test. The effervescent tablet formula was made in three formulas with the difference in the stevia content. Tests conducted include visual tests, uniformity test, hardness test, friability test, pH test and solubility test. Based on the test results on the physical properties of tablets, it is known that all the formula meets the physical test of tablets and the preferred formula is formula 3 with 4% of stevia.
Palm date fruits (Phoenix dactylifera L) have been used for medical treatment, one of the medical purpose as antioxidant, which is the coumpound for free radical scavenging. In this study used palm juice makes with non sentrifuged method by grounds 200 grams of palm fruit with 20 ml of aquadest and store in room temperature. For date palm syrup used in this study were from certain brand distributed on the market. Antioxidant activity was testing by using DPPH method and determined by spectrophotometry Uv-Vis in wavelength 517nm, and Total Phenolic Content was testing by Folin Ciocalteu method and determined by spectrophotometry Uv-Vis in wavelength 774nm. 11 sample of date palm syrup was sampling by purposive sampling methods and then got 2 sample to tested. Date Palm Juice were made by Non Cetrifuged methods. All sample were tested antioxidant activity using DPPH and Total Phenolic Content using Folin Ciocalteu. This study obtained that best operating time for all sample in antioxidant activity is 30 minutes with the highest point is Date Palm Juice 91,54%, Sample X for 86,93% and Sampel Y 89,92%. There was a linear correlation between with the result Total Phenolic Content for Date Palm Juice 9,25 mgGAE/g, Sample X 4,13 mgGAE/g and Sampel Y 4,28 mgGAE/g. Date Palm Juice and Date Palm Syrup could scavenge free radical DPPH in huge concentration and contain phenolic compound.
The results of previous studies on each concentration of 4000 ppm SPF value of sunscreen cream corncob extract (Zea mays L.) of 5.40. and SPF value of coffee bean extract cream (Coffea canephora Pierre ex A. Froehner) of 8.54. Both of these plant research results have SPF values that are still below 8 -15, so that further research is carried out using a mixture of the two extracts on a sun cream basis based on M / A basis. Methods: Making extracts of corncob mixture and Robusta coffee using a dose of 10%, and 15% and using a type A/M cream base. Cream testing includes physical and stability tests. Determination of the effectiveness of sunscreen cream preparations is done by testing the SPF value, antioxidant content and total phenolics in vitro using a UV / Vis spectrophotometer. Results: Cream stability test meets cream requirements. Formula 1 has an IC50 value of 198.61 ppm, a total phenol of 46 mGAE / g, at an SPF value of 35. Formula 2 has an IC50 value of 101.57 ppm, a total phenol of 59.9 mGAE / g, an SPF value of 38. Formula 3 has an IC50 value of 150.26 ppm, a total phenol of 51.45 mGAE / g and SPF 37. Conclusion: Sunscreen cream corn cobs extract and Robusta coffee has good stability, strong antioxidants, the highest phenol in formula 2, and are categorized as ultra sunblock
Menstrual pain is called dysmenorrhea; 15% of women who experience menstrual pain feel uncomfortable. Savitri & Swari (2020) stated that menstrual pain occurs 1-2 days before menstruation appears and continues until the third day of menstruation or the end. Some studies declare that ginger water decoction can reduce menstrual pain or dysmenorrhea. In vitro and in vivo, ginger has been shown to have antimicrobial, antifungal, anthelmintic, antioxidant, anti-inflammatory, antitumor, immunomodulatory, antilipidemic, analgesic properties, and protective effects on the digestive tract. Likewise, cinnamon and cloves can relieve toothache. This research method uses a quasi-experimental design with control by giving ginger and cinnamon spice drinks. The population of this study was women aged 19-21 years who experienced menstrual pain with a large sample of the results of the calculation of the average difference test in two pairs of groups, which were 30 respondents in each group, both intervention, and control. The study found that a spiced drink consisting of red ginger, cloves, and cinnamon and given honey positively affected menstrual pain (dysmenorrhea) with the p-value. There is an effect of a spiced drink consisting of red ginger, cloves, and cinnamon and given honey on menstrual pain (dysmenorrhea).
Indonesia has several plants that can be developed into cancer drugs. This study aims to make tablet preparations containing Paliasa leaf extract to produce pharmaceutical preparations for anticancer use. Paliasa leaves were extracted by maceration using 70% alcohol; then, the tablets were made using the wet granulation method. The extract obtained from 2,207 kg of dried simplicia paliasa leaves was 542 grams, with a yield of 24.56%. The flavonoid content in the extract was 1.79%, and the tablet was 0.75%. There are active compounds, namely 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl, a powerful antioxidant blend, hexadecanoic acid, or palmitic acid functions as an antibacterial and antioxidant, and kaempferol is one of the compounds, which has potential as an anticancer. The identification of extracts and tablets of paliasa leaf (Kleinhovia hospital Linn) resulted in IC50 above > 30 ppm in the inactive category, so the bioactivity of paliasa leaf extract was studied further fractionation.
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