GİRİŞZehirlenme vücuda zararlı olabilecek maddelerin ağız, solunum, damar yolu veya cilt gibi yollardan alınmasıdır (1) . Aşılar ve gelişmiş medikal tedavilerle infeksiyonların azalmasından sonra zehirlenmeler çocukluk çağında kazalar ve tümöral hastalıklarla beraber en önemli mortalite nedenlerini oluşturmak-tadır. Acil başvurularda trafik kazaları, düşme ve yanıklardan sonra zehirlenmeler çocukluk çağı kazaları

The incidence of latex sensitization in this study was lower than reported in the literature. Environmental factors such as the type and number of operations and geographical location may play a role in the development of latex sensitization.

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Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in the control group. In addition, serum amyloid A (SAA), and fibrinogen levels were measured, and a mutation analysis was performed in the patient group. The results were compared among the attackfree period, acute attack FMF and control groups. Results: The mean age of patients and control group was 10 (2.5-18) and 9.5 (2.5-16) years, respectively. The CRP (p = 0.001), S100A12 (p = 0.003) and ESR (p= 0.001) values differed significantly between the FMF and control groups. S100A12 level (p = 0.027), WBC count (p = 0.003), CRP level (p = 0.0001), ESR (p = 0.004), and fibrinogen level (p = 0.001) differed significantly between the acute attack and attack-free period groups. SAA level (p = 0.05), ESR (p = 0.001), fibrinogen level (p = 0.001), WBC count (p = 0.001), and S100A12 level (p = 0.027) were higher in M694V homozygous FMF patients than in other FMF patients. 2 Conclusion: Patients with FMF had higher S100A12 levels than the control group, while the mean S100A12 concentration was higher in acute attack period patients than in attackfree period patients. S100A12 level might be an important indicator in the monitoring of chronic inflammation in patients with FMF.

Ge liş ta ri hi/Re cei ved: 04.03.2015 Ka bul ta ri hi/Ac cep ted: 15.05.2015 Giriş Salmonella enfeksiyonları dünyada yaygın olarak görülmektedir ve enterik ateş mortalitesi yüksek invaziv bir enfeksiyondur. Non-tifoidal Salmonella enfeksiyonları ise genellikle kendini sınırlayan gastroenteritler şeklinde karşımıza çıkmaktadırlar, ancak özellikle yaşlılık ve yenidoğan dönemi, malign hastalıklar, uzun süren kortikosteroid kullanımı, Human İmmundeficiency Virus (HIV) enfeksiyonu gibi immün sistemin baskılandığı durumlarda barsak duvarına penetre olan mikroorganizma ishal sonrası bakteriyemiye neden olmaktadır (1). Bakteriyemi ile beraber özellikle immun yetmezliği bulunan bireylerde karaciğer, dalak, beyin, kalp, kemik, deri ve kasta fokal abse odaklarına neden olabilmektedir (1-3). Salmonella türlerinin neden olduğu gluteal abse erişkinlerde görülmekle beraber bugüne kadar çocuklarda bildirilmemiştir (4-6). Burada daha önceden bilinen bir hastalığı bulunmayan 13 aylık bir kız çocuğunda ishal sonrası gelişen bir gluteal abse olgusu sunulmuştur. Olgu Sunumu On üç aylık kız hasta birkaç gün içinde giderek artan, sol gluteal bölgede daha fazla olmak üzere her iki gluteal bölgede kızarıklık, şişlik ve ateş yakınmalarıyla hastanemize getirildi. Hastanın on gün öncesine kadar yurtdışında yaşadığı ve orada iki ay süren ishal nedeniyle adını bilmedikleri antibiyotikleri oral yoldan ve gluteal bölgeden intramusküler olarak aldığı ve ishalinin düzeldiği öğrenildi. Aralarında akrabalık olmayan ABS tRACt Özet The non-typhoidal Salmonella infections normally cause self-limiting gastroenteritis; but invasive gastroenteritis may occur, especially in newborns, elderly and immunosuppresive patients. In addition to bacteriemia, it may cause severe infections such as meningitis, brain abscess, septic arthritis and soft tissue abscesses. Muscle abscesses caused by non-typhoid salmonella infections have been rarely reported in adults. Here, a 13-month-old girl who developed gluteal abscess due to Salmonella typhimirium after diarrhea is presented.

Background: Tal et al. severity score (TSS) and Modified Wood’s Clinical Asthma Score (M-WCAS) are used to evaluate the severity of the disease in children with bronchiolitis. It has recently been suggested that there is a relationship between bronchiolitis severity and hyponatremia. Aims and Objective: This study aimed to evaluate the relationship between both of scores and hyponatremia in children with bronchiolitis. Materials and Methods: This prospective observational study included 172 patients (age range: 1-24 months) admitted to the hospital with bronchiolitis diagnosis. Demographic and clinical features of patients were recorded, and the TSS and the M-WCAS were calculated. These values and their components were compared with serum sodium (Na) results obtained at hospital admission. Results: Of the 172 patients, 114 (66.3%) were male, and the mean age was 5.5 ± 4.6 months. The mean TSS and M-WCAS of the patients were 6.73±1.9, and 3.34±1.4, respectively. Hyponatremia (Na<135mEq/L) was detected in 30 (17.4%) patients. When the TSS and M-WCAS of patients with and without hyponatremia were compared, there was no statistically significant difference (p = 0.517; p = 0.662, respectively); however, there was a significant relationship between hyponatremia and low oxygen saturation levels (p= 0.026). Conclusion: No relationship was found between hyponatremia and TSS & M-WCAS. However, the relationship between hyponatremia and hipoxia suggests that hyponatremia is likely to increase with the severity of the disease.

Kawasaki disease is common in children and is an acute systemic vasculitis affecting coronary arteries. Kawasaki disease has multisystemic nature with a variety of presenting symptoms. Without treatment 20-25% of Kawasaki disease patients develop coronary artery aneurysms. Our goal is to summarize the clinical data of patients treated with Kawasaki disease at our clinics. Material and Methods: Clinical features, laboratory findings, diagnosis and treatment of 21 patients with Kawasaki disease hospitalized at Turkish Ministry of Health Okmeydanı Training and Research Hospital, Clinic of Pediatrics during January 2009 to January 2015 were retrospectively evaluated.Results: The patients were between 9 and 67 months old (median 27.52± 18.78), 71.4% (n:15) were male. The duration of disease before diagnosis was 7.1±3.48 days, median 6 days. All patients had fever. The most common clinical features were oral cavity changes 95.2% (n:20), rash 85.7% (n:18), conjunctival injection 71.4% (n:15), extremity changes 61,9% (n:13), cervical lymphadenopathy 57.1% (n:12). We also observed sterile pyuria in 33.3%, desquamation of perianal area 28.6 %, aseptic meningitis in 9.5%, hydrops of the gallblader 4.8%. 19.1% patients had incomplete Kawasaki disease. 6 patients, 28.5% had coronary artery abnormalities. Intravenous immunglobulin treatment failure was observed in 9.5% of patients, one of them was diagnosed as macrophage activation syndrome. Conclusion: Kawasaki disease has difficulty in diagnosis because of having broad spectrum of presenting symptoms. Early diagnosis and treatment is very important in preventing coronary artery abnormalities.

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