ObjectivesThe aim of this study was to explore the risk of target organ damage (TOD) in different groups based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations.MethodsThe study cohort was divided into four groups according to the status of cfPWV and CBP [Group (cfPWV/CBP): high cfPWV and high CBP; Group (cfPWV): high cfPWV and normal CBP; Group (CBP): normal cfPWV and high CBP; Group (control): normal cfPWV and normal CBP]. TOD was determined by the assessment of carotid intima-media thickness (CIMT) abnormality, chronic kidney disease (CKD), microalbuminuria, and left ventricular hypertrophy (LVH).ResultsA total of 1,280 patients (mean age 53.14 ± 12.76 years, 64.1% male patients) were recruited in this study. Regarding Group (control) as reference, LVH was significantly higher in Group (cfPWV) and Group (CBP) [OR 2.406, 95% CI (1.301–4.452), P < 0.05; OR 2.007, 95% CI (1.335–3.017), P < 0.05]; microalbuminuria was significantly higher in Group (cfPWV/CBP) and Group (CBP) [OR 3.219, 95% CI (1.630–6.359), P < 0.05; OR 3.156, 95% CI (1.961–5.079), P < 0.05]. With age stratified by 60 years, the risk of CKD was significantly higher in Group (cfPWV/CBP) [OR 4.019, 95% CI (1.439–11.229), P < 0.05].ConclusionDifferent phenotypes based on the status of cfPWV and CBP were associated with different TOD. Individuals with both cfPWV and CBP elevated have a higher risk of microalbuminuria.
Background: Carotid-femoral pulse wave velocity (cfPWV) and ejection duration (ED) have different impacts on target organ damage (TOD). The aim of this study was to determine the relationship of cfPWV and ED with TOD. Methods: A total of 1254 patients (64.27% males) from Ruijin Hospital were enrolled in this study from December 2018 to August 2022. Medical records, blood samples and urine samples were collected. The cfPWV was measured and ED was generated using SphygmoCor software (version 8.0, AtCor Medical, Sydney, Australia). TOD including left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT) were evaluated. Results: Multiple stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) (β = 0.131, p = 0.002) and Log (albumin-creatinine ratio, ACR) (β = 0.123, p = 0.004), while ED was negatively correlated with LVMI (β = -0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) (β = 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055-1.458, p = 0.009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975-0.992, p < 0.001). In the control group with normal cfPWV and normal ED, LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374-0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305-35.427, p = 0.023). Conclusions: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. cfPWV and ED affect each other, and together have an effect on LVH.
Objective: Target organ damage (TOD is affected differently by cardiac and vascular function parameters such as ejection duration (ED) and carotid-femoral pulse wave velocity (cfPWV). This study aimed to quantify the relative differences in relationship of TOD with ED and cfPWV. Design and method: The study was conducted in 1254 patients (64.27% males) from Ruijin Hospital (December 2018 to August 2022). All participants provided urine and blood samples and information from medical records. cfPWV was measured using applanation tonometry and leg cuff waveforms (SphygmoCor, AtCor Medical, Sydney, Australia), and ED was obtained from waveform features. TOD was assessed in terms of left ventricular hypertrophy (LVH), microalbuminuria, chronic kidney disease (CKD), and abnormality of carotid intima-media thickness (CIMT). Results: Stepwise linear regression models of cfPWV and ED (individually or together) showed that cfPWV was positively correlated with left ventricular mass index (LVMI) (beta = 0.131, p 0.002) and Log (albumin-creatinine ratio, ACR) (beta = 0.123, p = 0.004), while ED was negatively correlated with LVMI (beta = –0.244, p < 0.001) and positively correlated with the estimated glomerular filtration rate (eGFR) (beta = 0.115, p = 0.003). When cfPWV and ED were added separately or together in multiple stepwise logistic regression models, cfPWV was associated with CKD [odds ratio (OR) = 1.240, 95% confidence interval (CI) 1.055–1.458, p = .009], while ED was associated with LVH (OR = 0.983, 95% CI 0.975–0.992, p < 0.001). In the control group with normal cfPWV (< 10 m/s) and normal ED (range 281-321 ms), LVH was significantly lower in patients with high ED (OR = 0.574, 95% CI 0.374–0.882, p = 0.011), but significantly elevated in those with high cfPWV and low ED (OR = 6.799, 95% CI 1.305–35.427, p 0.023). Conclusions: cfPWV was more strongly associated with renal damage, while ED was more strongly associated with cardiac dysfunction. As an index of arterial stiffness, cfPWV has an influence on wave reflection which can affect and ED, with a combined effect on LVH.
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