Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

Bai, Yaya; Wang, Qian; Cheng, Di; Hu, Yifei; Chao, Huijuan; Avolio, Alberto; Tang, Biwen; Zuo, Junli

doi:10.3389/fcvm.2022.839875

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…After correcting for risk factors, we found that CDBP was independently associated with MAU in EHT. Other studies showed similar findings; for example, a cross-sectional study with 1,280 hypertensive patients found that CDBP greater than 90 mmHg was associated with MAU, changes in carotid artery intima-media thickness, and left ventricular hypertrophy [ 7 ]. However, some studies have also found that it is CPP that is a predictor of target organ damage.…”

Section: Discussionmentioning

confidence: 60%

“…The same conclusion was reached in studies on children and adolescents [ 19 ]. In patients with risk factors for kidney injury, an increase in CSBP was found to increase the risk of developing MAU [ 7 ]. In our study, peripheral BP and CBP were correlated with log24 h-UAE.…”

Section: Discussionmentioning

confidence: 99%

“…CPP is strongly associated with adverse cardiovascular events [ 4 ], contrast-induced nephropathy [ 5 ], and diabetic kidney damage [ 6 ]. CSBP and CDBP are associated with alterations in the carotid artery intima-media thickness, MAU, and left ventricular hypertrophy [ 7 ]. However, which indicator is more closely associated with MAU in EHT is not known.…”

Section: Introductionmentioning

confidence: 99%

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Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study

Li,

Yang,

Chou

et al. 2023

BMC Cardiovasc Disord

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Objective To study the development of microalbuminuria (MAU) in essential hypertension (EHT), we investigated the association of MAU with central blood pressure (CBP), direct renin concentration (DRC), plasma aldosterone (PA), and uric acid (UA). Method We determined 24 h-urinary albumin excretion (24 h-UAE) in patients with EHT who were hospitalized at TEDA International Cardiovascular Hospital from June 2020 to May 2022. We defined MAU as 24 h-UAE in the range of 30 mg/24 h to 300 mg/24 h. Univariate and multivariate analyses were conducted to determine the associations of MAU with CBP, DRC, PA, and UA in EHT, considering demographic and clinical information. We also plotted receiver operating characteristic curves (ROCs) for predicting MAU using these results. Results More than a quarter of patients (26.5%, 107/404, 95% CI: 22.2–31.1%) were diagnosed with MAU in EHT. A higher body mass index (BMI), longer duration of hypertension, and higher severity were associated with MAU. Also, nearly 10% more creatinine levels were recorded in the MAU group than in the control group (69.5 ± 18.7 µmol/L vs. 64.8 ± 12.5 µmol/L, P = 0.004). The increase was also observed for PA (15.5, 9.7–20.6 ng/dL vs. 12.3, 9.0–17.3 ng/dL, P = 0.024) and UA (419.8 ± 105.6 µmol/L vs. 375.1 ± 89.5 µmol/L, P < 0.001) in the MAU group compared to that in the control group. Several variables were associated with MAU, including central diastolic blood pressure (CDBP) (OR = 1.017, 95% CI: 1.002–1.032, P = 0.027), PA (OR = 1.043, 95% CI: 1.009–1.078, P = 0.012) and UA (OR = 1.005, 95% CI: 1.002–1.008, P < 0.001). For MAU prediction, the area under the curve (AUC) was 0.709 (95% CI: 0.662–0.753; P < 0.001) when CDBP, PA, and UA were used in combination, and the optimal probability of the cut-off value was 0.337. Conclusion We found that CDBP, PA, and UA, used for MAU prediction, might be associated with its development during EHT.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study

Li,

Yang,

Chou

et al. 2023

BMC Cardiovasc Disord

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“…The primary endpoint was to evaluate whether by using a therapeutic concordance approach a satisfactory BP control could be obtained in TRH patients. Secondary endpoints were: the percentage of hypertensive “difficult-to-control” patients (achieving BP control with the administration of more than three drugs [ 45 , 46 ]); the time course of target organ damage, defined by reduction in LVMha, carotid IMT, and GFR decline [ 47 ]; the incidence of major adverse CV events (MACE). The null hypothesis was rejected at a two-tailed p < 0.05.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic concordance improves blood pressure control in patients with resistant hypertension

Trimarco

Izzo

Mone

et al. 2023

Pharmacological Research

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“…It has emerged as the gold standard method to measure arterial stiffness [2,3]. An elevation of CfPWV is an essential indicator for vessels and target organ damage [4].…”

Section: Introductionmentioning

confidence: 99%

The Role of Carotid-Femoral Pulse Wave Velocity in a Metabolic Syndrome Patient with Sudden Cardiac Arrest: A Case Report

Choy,

Bogdański,

Skrypnik

2024

Healthcare

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Introduction: Carotid-femoral pulse wave velocity reflecting aortic stiffness could be used as an independent predictor of future cardiovascular events for an individual with metabolic syndrome. However, the routine use of carotid-femoral pulse wave velocity is suboptimized in clinical practice. We report a case of metabolic syndrome with increased carotid-femoral pulse wave velocity and subsequently developed myocardial infarction and sudden cardiac arrest. Case presentation: A Polish man of an age between 40 and 50 years previously diagnosed with metabolic syndrome with essential hypertension, obesity, dyslipidaemia, and impaired glucose level. He developed myocardial infarction, ventricular fibrillation, and was successfully resuscitated with defibrillation. The patient showed high–normal traditional cardiovascular risk factors but an increased carotid-femoral pulse wave velocity. The increased carotid-femoral pulse wave velocity is associated with an increased arterial stiffness, which altered the myocardial perfusion and induced the anterior-lateral ST elevation myocardial infarction. The patient actively participated and completed the phase II cardiac rehabilitation programme. To the best of our knowledge, there have been few studies on carotid-femoral pulse wave velocity screening for patients with metabolic syndrome. Pulse wave velocity screening by a physician appears to be helpful in identifying the potential high-risk population with borderline traditional cardiovascular risk factors. Conclusion: This trajectory highlights the clinical relevance of using carotid-femoral pulse wave velocity as an adjunct marker to assess the risk of cardiovascular event for patients with metabolic syndrome.

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Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

Cited by 4 publications

References 43 publications

Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study

Central diastolic blood pressure, plasma aldosterone and uric acid are associated with microalbuminuria in essential hypertension: a case-control study

Therapeutic concordance improves blood pressure control in patients with resistant hypertension

The Role of Carotid-Femoral Pulse Wave Velocity in a Metabolic Syndrome Patient with Sudden Cardiac Arrest: A Case Report

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