Role of herbal medicine and gut microbiota in the prevention and treatment of obesity

Zhang, Qiao; Bai, Yaya; Wang, Wenxiao; Li, Jiajia; Zhang, Li; Tang, Yuping; Yue, Shi‐Jun

doi:10.1016/j.jep.2022.116127

Cited by 13 publications

(4 citation statements)

References 151 publications

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“…However, it is at least well known that some biological aspects which are largely discussed in this review are tightly involved in the biological processes of obesity pathophysiology. Gut microbiota have been shown, for example, to be closely related to diverse macronutrient metabolisms and fat depositions, as well as to a large plethora of hormonal and other signaling pathways, making the dysbiosis of the micro-organism community involved in obesity inducement and worsening [ 220 , 221 ]. For instance, intestinal permeability, inflammatory processes, oxidative stress, epigenetic regulation, genetic predisposition, and, of course, imbalanced diet are certainly linked to obesity pathogenesis [ 220 , 222 , 223 ].…”

Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved in the genesis and development of many world-scale public health burdens, such as metabolic and cardiovascular diseases. In recent years, bee pollen is emerging as a scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix is being extensively studied, and has proven to be a very rich and well-balanced nutrient pool. In this work, we reviewed the available evidence on the interest in bee pollen as a nutrient source. We mainly focused on bee pollen richness in nutrients and its possible roles in the main pathophysiological processes that are directly linked to nutritional imbalances. This scoping review analyzed scientific works published in the last four years, focusing on the clearest inferences and perspectives to translate cumulated experimental and preclinical evidence into clinically relevant insights. The promising uses of bee pollen for malnutrition, digestive health, metabolic disorders, and other bioactivities which could be helpful to readjust homeostasis (as it is also true in the case of anti-inflammatory or anti-oxidant needs), as well as the benefits on cardiovascular diseases, were identified. The current knowledge gaps were identified, along with the practical challenges that hinder the establishment and fructification of these uses. A complete data collection made with a major range of botanical species allows more robust clinical information.

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Section: Resultsmentioning

confidence: 99%

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Kacemi,

Campos

2023

Nutrients

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“…Obesity, one of the biggest challenges to public health worldwide to date, is also thought to be an important risk indicator for numerous other metabolic illnesses, such as hyperlipidemia, hypertension, myocardial infarction, stroke, type 2 diabetes as well as non-alcoholic fatty liver disorder, thereby contributing to a decline in quality of life and longevity ( 1 – 3 ). There has been a significant increase within the incidence of obesity globally, which is a major health risk to people and an important medical issue that needs to be resolved within various countries ( 2 , 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

Zhi,

Chang,

Wang

et al. 2024

Front. Nutr.

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Traditional Chinese medicine (TCM) has displayed preventive and therapeutic effects on many complex diseases. As natural biological macromolecules, TCM-derived antiobesogenic polysaccharides (TCMPOs) exhibit notable weight-loss effects and are seen to be a viable tactic in the fight against obesity. Current studies demonstrate that the antiobesity activity of TCMPOs is closely related to their structural characteristics, which could be affected by the extraction and purification methods. Therefore, the extraction, purification and structural-property correlations of TCMPOs were discussed. Investigation of the antiobesity mechanism of TCMPOs is also essential for their improved application. Herein, the possible antiobesity mechanisms of TCMPOs are systematically summarized: (1) modulation of appetite and satiety effects, (2) suppression of fat absorption and synthesis, (3) alteration of the gut microbiota and their metabolites, and (4) protection of intestinal barriers. This collated information could provide some insights and offer a new therapeutic approach for the management and prevention of obesity.

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“…The other detrimental effects caused by the dysbiosis are disruption in the energy metabolism, increased cell death, and modulation of immune response, which contributes to the advancement of various diseases ( Noble et al, 2017 ), adding to the pathogenic mechanisms of several disorders, including neurodegeneration ( Mulak and Bonaz, 2015 ). Dysbiosis has been linked to several other diseases, including: (a) Inflammatory Bowel Disease (IBD): dysbiosis in the GM gut microbiome is associated with IBD, and other gut related disorder like Crohn’s disease and ulcerative colitis ( Di Martino et al, 2023 ); (b) Irritable Bowel Syndrome (IBS): it is associated with dysbiosis, which is characterized by abdominal pain and altered bowel habits ( Körner and Lorentz, 2023 ); (c) Obesity: GM is associated with obesity and has been linked with the dysbiosis due to increased body weight and fat accumulation ( Zhang et al, 2023 ); (d) Type 2 diabetes (T2DM): various studies have demonstrated correlation of T2DM with dysbiosis and stated that may dysbiosis is a contributing factor to T2DM ( He et al, 2023 ); (e) Allergies and Asthma: dysbiosis in the gut and respiratory microbiome has been associated with an increased risk of allergies and asthma ( Kleniewska and Pawliczak, 2023 ); (f) Mental Health disorders: dysbiosis in the gut microbiome has been linked to mental health disorders, including depression, anxiety, and autism ( Młynarska et al, 2022 ); (g) Autoimmune Diseases: dysbiosis in the GM is correlated with autoimmune diseases, including rheumatoid arthritis (RA) and multiple sclerosis (MS; Ordoñez-Rodriguez et al, 2023 ). In addition, variation in the diversity of GM is associated with aging and aging gut demonstrated a decrease in the microbial diversity ( Cheng et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of gut microbiota on neurodegenerative diseases

Khatoon

Kalam

Rashid

et al. 2023

Front. Aging Neurosci.

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A progressive degradation of the brain’s structure and function, which results in a reduction in cognitive and motor skills, characterizes neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). The morbidity linked to NDs is growing, which poses a severe threat to human being’s mental and physical ability to live well. The gut-brain axis (GBA) is now known to have a crucial role in the emergence of NDs. The gut microbiota is a conduit for the GBA, a two-way communication system between the gut and the brain. The myriad microorganisms that make up the gut microbiota can affect brain physiology by transmitting numerous microbial chemicals from the gut to the brain via the GBA or neurological system. The synthesis of neurotransmitters, the immunological response, and the metabolism of lipids and glucose have all been demonstrated to be impacted by alterations in the gut microbiota, such as an imbalance of helpful and harmful bacteria. In order to develop innovative interventions and clinical therapies for NDs, it is crucial to comprehend the participation of the gut microbiota in these conditions. In addition to using antibiotics and other drugs to target particular bacterial species that may be a factor in NDs, this also includes using probiotics and other fecal microbiota transplantation to maintain a healthy gut microbiota. In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.

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Role of herbal medicine and gut microbiota in the prevention and treatment of obesity

Cited by 13 publications

References 151 publications

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Recent advances in the extraction, purification, structural-property correlations, and antiobesity mechanism of traditional Chinese medicine-derived polysaccharides: a review

Effects of gut microbiota on neurodegenerative diseases

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