The synthesis is decribed of an octadecapeptide, glycyl-tyrosyl-seryl-methionyl-glutamyl-histidyl-phenyl-alanyl-arginyl-tryptophyl-glycyl-lysyl-prolyl-valyl-glycyl-lysyl-lysyl-arginyl-arginine amide, corresponding to the first eighteen amino acid residues of corticotropin except for the amino end which has been replaced by a glycine for the serine in the native hormone. The protected end product was obtained by two different coupling procedures, the active ester and the catalyzed carbodiimide, from the amino-terminal decapeptide and the octapeptide of carboxyl end. The over-all yields of the peptide, for the final coupling, deblocking and purification steps, in the active ester and the carbodiimide procedures were approximately forty and thirty per cent, respectively. The synthetic octadecapeptide amide has been shown to possess a high adrenal corticotropic activity, which is comparable to that of the corresponding 1-serine octadecapeptide amide, and a lipolytic activity which is significantly lower than that of the 1-serine analog.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.