Studies on Peptides. XXIII. Total Synthesis of Monkey β-Melanocyte-stimulating Hormone

Yajima, Haruaki; Okada, Yoshio; Kinomura, Yasuhiko; Mizokami, Nariakira; Kawatani, Hiroki

doi:10.1248/cpb.17.1237

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1970

1981

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“…Asp-Gly-Gly-Pro-Tyr-Lys-Met-Gin-His-Phe-1 5 10 Ar g-Trp-Gly-Ser-Pro-Pro-Lys-Asp-OH 15 In comparison with the structure of bovine /3-MSH (Geschwind et al, 1957), it is designated as [Gly2Gln8]-/?b-MSH or /3ci-MSH.2 Bovine (Schwyzer et al, 1963), human (Yajima et al, 1969), and macaque (Yajima et al, 1970) /3-melanotropins have been synthesized by solution methods. Recently, the human and monkey hormones have been synthesized (Wang et al, 1973) using the solid-phase procedure (Merrifield, 1964).…”

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confidence: 99%