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Webpage design has become an important component affecting user satisfaction when they surf the Internet. Interface designers are struggling to improve the quality of user experience by designing webpages that meet users’ emotional needs. An optimization design method of webpage interface is proposed in this study based on Kansei engineering theory, and a job‐hunting website homepage is taken as the research example. After determining the materials, the semantic differential (SD) method is used to extract user‐centered emotional dimensions, and the key design factors of homepages’ appearance are acquired. Next, based on the obtained semantic differential evaluation data, back propagation neural network (BPNN) is conducted to identify quantitative relations between key design factors and emotional dimensions. Finally, genetic algorithm (GA) is employed to search for a near‐optimal design. The proposed method is helpful to design webpages that can satisfy participants’ emotions. It can also be used in a variety of design cases.

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Background: Hypoxic-ischaemic encephalopathy (HIE) is a prevailing severe brain damage disease in newborns, and caused by perinatal asphyxia cerebral ischaemia and reperfusion. Here, we investigated the role of cZNF292 in oxygen-glucose deprivation/reperfusion (OGD/R)-induced neural stem cells (NSCs) injury, and explored the underlying molecular mechanism. Methods: Before NSCs were subjected to OGD/R treatment, NSCs were transfected with or without overexpressing cZNF292, si-cZNF292 or miR-22 inhibitor. Viability, apoptosis and potential molecular mechanism were examined. Cell viability and apoptotic rate were evaluated utilizing cell counting kit-8 (CCK-8) and flow cytometry. The cZNF292 and miR-22 expression was determined utilizing quantitative reverse transcription-PCR (qRT-PCR). Moreover, apoptosis and Wnt/b-catenin and PKC/ERK pathwaysassociated proteins were quantified applying western blot. Results: OGD/R repressed viability and promoted apoptosis of NSCs. Also, cZNF292 expression was promoted by OGD/R treatment. Moreover, cZNF292 overexpression further caused OGD/R-stimulated damage. Inversely, silencing cZNF292 alleviated OGD/R-stimulated damage in NSCs. In addition, miR-22 expression was negatively regulated by cZNF292. It was confirmed that silencing cZNF292 attenuated OGD/R-induced NSCs injury and promoted the activation of Wnt/b-catenin and PKC/ERK pathways via the up-regulation of miR-22. Conclusions: The cZNF292 silence alleviated OGD/R-induced injury through the up-regulation of miR-22 in NSCs, and which furnished the theoretical basis for further research on HIE progression.

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Emotions play an important role in the design of e-commerce websites. A website should satisfy its users' emotional needs. Emotion measurement is a prerequisite to understanding users' emotional needs; because emotions contain complicated components, they are difficulty to measure. To interpret users' emotional experiences while the users are interacting with e-commerce websites, we propose a multimodal measurement method conjoint using questionnaires, eye tracking, and physiological measures. The effects of various websites on users' emotions and the relationship between users' subjective emotional ratings, eye movements, and physiological responses, along with the effects of their emotions on behavior intentions, were analyzed. The results indicate that differences in users' emotional experiences while shopping on various e-commerce websites are primarily embodied in subjective emotional ratings and eye movements. There is a correlation between users' subjective emotional ratings, eye movements, and physiological responses, and to some extent, users' emotional experiences can affect their behavior intentions. C 2014 Wiley Periodicals, Inc.

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