Innovation is the primary driving force for development and the core of green, healthy, and sustainable economic development. This paper researches the spatial effect of absorptive capacity on regional innovation capacity from the perspective of knowledge spillover. We use the seven dimensions such as R & D intensity to build an absorptive capacity index evaluation system. After statistical verification, we select the most suitable empirical model, the dynamic Spatial Durbin Model with two-way fixed effect. The empirical results show that: (1) The promotion effect of absorptive capacity on knowledge spillovers in one province has no obvious effect on innovation promotion in other provinces, especially provinces at similar economic levels. However, it tends to inhibit the innovation development of neighboring provinces. (2) The impact of absorptive capacity on promoting knowledge spillovers varies from region to region. The eastern provinces of China are not affected by the absorptive capacity of neighboring provinces. The regression results of the central and western regions are not substantially different from the full sample. This study puts forward some policy suggestions based on the empirical results. It shows that a higher absorptive capacity does not mean better performance. The Chinese government should thus promote innovation in different provinces according to the local conditions. Sustainability 2020, 12, 3021 2 of 23 Although China has already become the second largest economy in the world, its comprehensive innovation capacity is relatively weak. Up to now, there have been some problems in China's innovation development, such as imbalance and inadequacy. Population and resource mismatches and weak industrial sustainability are already prominent. The Chinese government has given long-term attention and support to innovation development. President Xi Jinping has repeatedly stressed at various conferences that innovation development is urgent. The National Innovation Blue Book: China Innovation Development Report (2016) summarizes the situation: "There are two major constraints on China's innovation development. One is the insufficient use of innovation resources; the other is the insufficient economic transformation rate of innovation results." In view of the above, after consulting the relevant literature, this paper found that the two ratios are closely related to knowledge elements and absorptive capacity. Knowledge is an important factor in innovation development, and its spillover has a significant effect on sustainable economic development [1]. Absorptive capacity also plays a positive role in this process [2]. Nieto and Quevedo emphasized that only when external knowledge is absorbed is the entire spillover process complete. In addition, absorptive capacity is the key to improving spillover efficiency.[3] EgbeTokun and Savin explained that a region with high absorptive capacity can quickly transform received knowledge into expected economic output and realize benefits [4].Based on the above, thi...
In recent years, urbanization has been developing rapidly. However, it is also accompanied by land management problems, such as low land use efficiency. In this research, we manage to explore the temporal and spatial evolution laws as well as characteristics of the coupling and coordinated development between urbanization and land use benefits. Through this, it is possible for us to provide policy recommendations for the sustainable development of the urbanization in Fujian Province. In this study, we take prefecture-level municipal districts and county-level cities in Fujian as the research subject. We construct an index system, based on data in 2002, 2005, 2010, 2015, and 2017, to evaluate the urban land use benefits and urbanization. Besides, we leverage the Gini coefficient weighting method to give weight to each index and calculate the value of its benefits. Moreover, it is the relative development degree and the coupling coordination degree model that we comprehensively leverage to study the spatiotemporal evolution law of the coupling coordination degree (CCD). The results show that: (1) Urban land use benefits and urbanization level are positively correlated with the regional administrative level and economic development status; (2) The CCD of urban land use benefits and urbanization level in various regions of Fujian is still low. However, the overall development direction is good; (3) From the perspective of spatial distribution, the CCD owns a “center-periphery” pattern that is based on the law of diminishing CCD power from three central cities of Fuzhou, Xiamen, and Sanming. Consequently, it requires governments to take action. Firstly, they should promote the intensive land use in the urbanization process. Meanwhile, they should also pay attention to ecological environment protection. Besides, it is recommendable to give full play to the radiating and leading effect of central cities on surrounding ones. Finally, they are required to provide appropriate policies and resource support to peripheral cities.
Perivascular adipose tissue (PVAT) is the connective tissue around most blood vessels throughout the body. It provides mechanical support and maintains vascular homeostasis in a paracrine/endocrine manner. Under physiological conditions, PVAT has anti-inflammatory effects, improves free fatty acid metabolism, and regulates vasodilation. In pathological conditions, PVAT is dysfunctional, secretes many anti-vasodilator factors, and participates in vascular inflammation through various cells and mediators; thus, it causes dysfunction involving vascular smooth muscle cells and endothelial cells. Inflammation is an important pathophysiological event in many vascular diseases, such as vascular aging, atherosclerosis, and hypertension. Therefore, the pro-inflammatory crosstalk between PVAT and blood vessels may comprise a novel therapeutic target for the prevention and treatment of vascular diseases. In this review, we summarize findings concerning PVAT function and inflammation in different pathophysiological backgrounds, focusing on the secretory functions of PVAT and the crosstalk between PVAT and vascular inflammation in terms of vascular aging, atherosclerosis, hypertension, diabetes mellitus, and other diseases. We also discuss anti-inflammatory treatment for potential vascular diseases involving PVAT.
Gastrocutaneous fistula caused by mesh migration following diaphragmatic rupture repair A 60-year-old female was involved in a traffic accident, presented with blunt thoracoabdominal trauma and admitted to our department in November 2018. Abdominal exploration revealed ruptured spleen and gastric herniation caused by left hemidiaphragm rupture. The burst spleen was surgically removed and the stomach was brought down into the abdomen. We noticed a radial defect about 10-cm-long in the posterolateral aspect of the left diaphragm which could not be repaired primarily. Thus, we decided to reinforce the repair using a synthetic mesh secured to the diaphragm circumferentially overlapping the margins with interrupted suture. However, the postoperative complication occurred after being symptom-free for 2 years. She returned to our department in June 2022 with complaints of yellowish discharge from the left upper abdomen wound.The patient's symptoms were self-limiting throughout the past year. There was no abdominal pain or detectable fever, and the wound outflow was maintained at a few millilitres per day. Abdominal CT showed that the mesh had migrated into the stomach and subcutaneous tissue. Gastrointestinal contrast revealed a fistulous tract extending from the stomach to the abdominal wall, which confirmed the presence of gastrocutaneous fistula (Fig. 1). Combined with the above symptoms and imaging examinations, we performed exploratory laparotomy and found dense adhesion between the stomach, diaphragm, and abdominal wall. Fortunately, the defect was not noted in the diaphragm. Finally, we confirmed that the mesh had moved from the stomach to the subcutaneous tissue during the procedure (Fig. 2), and the infected mesh was eliminated (Fig. 3). The fistula-forming anterior gastric wall was resected en bloc with the fistula. Subsequent gastrorrhaphy was created using the proximate linear cutter stapler. Primary fascial closure was used to fix the narrow ventral defect, and the laparotomy wound was closed in layers. The
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