Role of Inflammation in Vascular Disease-Related Perivascular Adipose Tissue Dysfunction

Chen, Yaozhi; Qin, Zeying; Wang, Yaqiong; Li, Xin; Zheng, Yang

doi:10.3389/fendo.2021.710842

Cited by 18 publications

(14 citation statements)

References 136 publications

(170 reference statements)

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“…This finding confirms the relation between dysfunctional perivascular adipose tissue, inflammation and vascular disease. In physiological conditions, perivascular fat has an anti-inflammatory role, whereas age can modify its function to pro-inflammatory (e.g., endothelin-1, inducible NOS and cyclooxygenase 2) [169]. The pro-inflammatory vascular environment is associated with low-grade perivascular inflammation, creating a vicious cycle with development of AS.…”

Section: All About Eva (Early Vascular Aging)mentioning

confidence: 99%

Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging

Barbu

Popescu

et al. 2022

IJMS

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Vascular disease was for a long time considered a disease of the old age, but it is becoming increasingly clear that a cumulus of factors can cause early vascular aging (EVA). Inflammation plays a key role in vascular stiffening and also in other pathologies that induce vascular damage. There is a known and confirmed connection between inflammation and atherosclerosis. However, it has taken a long time to prove the beneficial effects of anti-inflammatory drugs on cardiovascular events. Diabetes can be both a product of inflammation and a cofactor implicated in the progression of vascular disease. When diabetes and inflammation are accompanied by obesity, this ominous trifecta leads to an increased incidence of atherothrombotic events. Research into earlier stages of vascular disease, and documentation of vulnerability to premature vascular disease, might be the key to success in preventing clinical events. Modulation of inflammation, combined with strict control of classical cardiovascular risk factors, seems to be the winning recipe. Identification of population subsets with a successful vascular aging (supernormal vascular aging—SUPERNOVA) pattern could also bring forth novel therapeutic interventions.

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Section: All About Eva (Early Vascular Aging)mentioning

confidence: 99%

Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging

Barbu

Popescu

et al. 2022

IJMS

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“…It is also highly likely that perivascular adipose tissue (PVAT), which is known to surround most blood vessels [45], plays a role in driving inflammation after PCI. PVAT is a connective tissue comprised of a mix of cell types, including adipocytes, preadipocytes, mesenchymal stem cells, fibroblasts, vascular and nerve cells, and, importantly, inflammatory cells (macrophages, lymphocytes and eosinophils) [46]. Under pathological conditions, PVAT expands, becomes dysfunctional and initiates inflammatory crosstalk with the blood vessels [46].…”

Section: Vascular Inflammationmentioning

confidence: 99%

“…PVAT is a connective tissue comprised of a mix of cell types, including adipocytes, preadipocytes, mesenchymal stem cells, fibroblasts, vascular and nerve cells, and, importantly, inflammatory cells (macrophages, lymphocytes and eosinophils) [46]. Under pathological conditions, PVAT expands, becomes dysfunctional and initiates inflammatory crosstalk with the blood vessels [46]. TNF-α, IL-6, IL-1β and MCP-1 levels are increased in PVAT associated with atherosclerosis [47,48].…”

Section: Vascular Inflammationmentioning

confidence: 99%

The Mechanisms of Restenosis and Relevance to Next Generation Stent Design

et al. 2022

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Stents are lifesaving mechanical devices that re-establish essential blood flow to the coronary circulation after significant vessel occlusion due to coronary vessel disease or thrombolytic blockade. Improvements in stent surface engineering over the last 20 years have seen significant reductions in complications arising due to restenosis and thrombosis. However, under certain conditions such as diabetes mellitus (DM), the incidence of stent-mediated complications remains 2–4-fold higher than seen in non-diabetic patients. The stents with the largest market share are designed to target the mechanisms behind neointimal hyperplasia (NIH) through anti-proliferative drugs that prevent the formation of a neointima by halting the cell cycle of vascular smooth muscle cells (VSMCs). Thrombosis is treated through dual anti-platelet therapy (DAPT), which is the continual use of aspirin and a P2Y12 inhibitor for 6–12 months. While the most common stents currently in use are reasonably effective at treating these complications, there is still significant room for improvement. Recently, inflammation and redox stress have been identified as major contributing factors that increase the risk of stent-related complications following percutaneous coronary intervention (PCI). The aim of this review is to examine the mechanisms behind inflammation and redox stress through the lens of PCI and its complications and to establish whether tailored targeting of these key mechanistic pathways offers improved outcomes for patients, particularly those where stent placement remains vulnerable to complications. In summary, our review highlights the most recent and promising research being undertaken in understanding the mechanisms of redox biology and inflammation in the context of stent design. We emphasize the benefits of a targeted mechanistic approach to decrease all-cause mortality, even in patients with diabetes.

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“…Vascular damage caused by external force invasion or vascular disease is the leading cause of death worldwide [ 1 , 2 , 3 ]. For minor vascular damage clinically, simple surgical sutures and medical treatment can be used for treatment.…”

Section: Introductionmentioning

confidence: 99%

Vascular Repair by Grafting Based on Magnetic Nanoparticles

et al. 2022

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Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.

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Role of Inflammation in Vascular Disease-Related Perivascular Adipose Tissue Dysfunction

Cited by 18 publications

References 136 publications

Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging

Inflammation as A Precursor of Atherothrombosis, Diabetes and Early Vascular Aging

The Mechanisms of Restenosis and Relevance to Next Generation Stent Design

Vascular Repair by Grafting Based on Magnetic Nanoparticles

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