In this paper, a new double micropipettes configuration mode of scanning ion conductance microscopy (SICM) is presented to better overcome ionic current drift and further improve the performance of SICM, which is based on a balance bridge circuit. The article verifies the feasibility of this new configuration mode from theoretical and experimental analyses, respectively, and compares the quality of scanning images in the conventional single micropipette configuration mode and the new double micropipettes configuration mode. The experimental results show that the double micropipettes configuration mode of SICM has better effect on restraining ionic current drift and better performance of imaging. Therefore, this article not only proposes a new direction of overcoming the ionic current drift but also develops a new method of SICM stable imaging.
STM may open a new way to probe the molecular structure of the lipids and proteins on the membrane of living cells. In this paper, the surface structure of noncoated membrane of microphages in water was studied by STM. We probed the lipids and proteins on the membrane before and after ConA was combined with the membrane receptors. Results with different patterns were obtained. An experiment with optical microscopic image analysis system has also been done.
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