Development of DM in ACC can be predicted by solid histologic subtype and major salivary gland or oral/pharyngeal rather than sinonasal primary site. Those patients with bone involvement with or without lung metastases had worse outcomes than those with pulmonary metastasis only.

Histoimmunological characteristics of non-eosinophilic NPs differ from those of eosinophilic NPs; non-eosinophilic NPs may be featured by thinner BM and fewer CCR5- and CCR3-positive lymphocytes.

Objectives: Malignancies arising from the sinonasal tract, which includes the nose, paranasal sinuses, and nasopharynx, are uncommon. Although adenoid cystic carcinoma (ACC) is the second most common cancer occurring in the sinonasal tract, only few studies have been reported. This retrospective review was performed to identify the clinical features and treatment outcomes of sinonasal ACC. Methods: Thirty-five patients diagnosed and treated for ACC of the sinonasal tract were included in this study. Medical records, radiographs, and pathologic slides were retrospectively reviewed. Results: In two thirds of the patients, the maxillary sinus was the site of origin and cribriform was the most common histologic subtype (61%). Seventy-one percent of the patients had advanced disease (T3, T4) at the time of diagnosis. Five-year overall survival rate was 86% and treatment failure occurred in 18 patients (51%). Five-year local recurrence rate and distant metastasis rate were 30% and 25%, respectively. Adjunctive radiotherapy appeared to reduce local recurrence. Presence of distant metastasis correlated with decreased 5-year survival (P ‫؍‬ .001). Five-year survival rate after development of distant metastasis or local recurrence were 17% and 58%, respectively. Conclusions: Based on our findings, we suggest that sinonasal ACC be treated by a combined modality of radical surgery followed by postoperative radiation. The prognosis of sinonasal ACC seems to be determined by the presence of distant metastasis.

hNECs undergo EMT during hypoxia and this process is critically mediated by HIF-1α and pSmad3. This study shows that hypoxia-induced EMT is likely to contribute to nasal polyposis in CRS, and suggests that HIF-1α be viewed as a therapeutic target for nasal polyposis.

At 8 weeks postoperatively, the severity and the frequency of nasal obstruction improved subjectively in 81.3% and 93.8% of RFTVR group and in 87.5% and 87.5% of LVT group, respectively. Significant improvement of nasal symptoms began from 2 to 3 days after the operation in the RFTVR group, whereas there was significant improvement of nasal symptoms at 8 weeks after operation in the LVT group. However, objective nasal functions including nasal volume and total nasal resistance were significantly improved at 8 weeks after surgery in both groups. Among patients reporting symptoms of hyposmia, 55.6% of RFTVR group and 63.6% of LVT group showed improved olfaction. Saccharin transit time and ciliary beat frequency were preserved after RFTVR CONCLUSION: RFTVR for the turbinate may be useful as an alternative approach for the treatment of chronic turbinate hypertrophy.

From July through October 1991, a nationwide survey was conducted on the prevalence and risk factors of chronic sinusitis in Korea, using medical and family histories as well as physical examination. In all, 9,069 subjects were examined from 2,899 households residing in 60 different areas throughout the country. The overall prevalence of sinusitis was 1.01%. Casecontrol analysis was performed to determine possible risk factors for sinusitis. No significant differences were found in age groups or sexes. A significant geographic difference was seen in prevalence in the different provinces studied. Economic activity, crowding and allergy were significant risk factors. Other factors such as urban or rural residence, birth place, maternal and paternal age at birth, marriage, smoking history, education, social class, prior trauma, height and weight, and nasal septal deformities did not correlate with the occurrence of sinusitis.

The authors aimed to evaluate the validity and characteristics of acoustic rhinometic tests by comparing the results with those of computed tomography (CT) of the nasal cavity. Cross-sectional areas along the nasal cavity were measured by acoustic rhinometry (AR) and CT of the nasal cavity in 30 normal subjects. Cross-sectional areas measured by each technique showed a statistically significant correlation. The two measurements showed a better linear correlation in the anterior part of the nasal cavity up to 24 mm from the nostril than in the posterior part of the nasal cavity beyond that point. Mean cross-sectional areas measured by AR were constantly less than those measured by CT of the nasal cavity up to 33 mm from the nostril, whereas areas measured by AR were greater than those measured by CT scans beyond that point.

No abstract