Generally, there were no significant differences in recurrence rates according to clinical stage or surgical approach. Given the rate of delayed recurrence, follow-up of >3 years is required. Moreover, surgeons should always consider combined approaches to reduce the chances of recurrence.
The boundaries between domains in single-layer graphene strongly influence its electronic properties. However, existing approaches for domain visualization, which are based on microscopy and spectroscopy, are only effective for domains that are less than a few micrometres in size. Here, we report a simple method for the visualization of arbitrarily large graphene domains by imaging the birefringence of a graphene surface covered with nematic liquid crystals. The method relies on a correspondence between the orientation of the liquid crystals and that of the underlying graphene, which we use to determine the boundaries of macroscopic domains.
hNECs undergo EMT during hypoxia and this process is critically mediated by HIF-1α and pSmad3. This study shows that hypoxia-induced EMT is likely to contribute to nasal polyposis in CRS, and suggests that HIF-1α be viewed as a therapeutic target for nasal polyposis.
An artificial ionic mechanotransducer skin with an unprecedented sensitivity over a wide spectrum of pressure by fabricating visco-poroelastic nanochannels and microstructured features, directly mimicking the physiological tactile sensing mechanism of Piezo2 protein is demonstrated. This capability enables voice identification, health monitoring, daily pressure measurements, and even measurements of a heavy weight beyond capabilities of human skin.
Our results suggest that IL-25 secreted from the sinonasal epithelia and infiltrating mast cells plays a crucial role in the pathogenesis of CRS with NPs in Asian patients. In addition, our results suggest the novel possibility of treating nasal polyposis with anti-IL-25 therapy.
Lithium (Li) metal is the most ideal anode material in lithium ion batteries due to its large theoretical capacity (3860 mAh g −1 ) and low redox potential (−3.04 V vs standard hydrogen potential, H 2 /H + ). Nevertheless, surface dendrite formation during repeated charge−discharge cycles limits the cycle life and thus its practical use. The research efforts engaging polymer/ceramic coating or electrolyte additives have made noticeable progress, but further improvement is still desirable. Here, we report significantly improved performance by a synergistic effect of multilayered graphene (MLG) coating and Cs + additive in the electrolyte. MLG separates solid-electrolyte-interphase (SEI) formation from Li dendrites and thus stabilizes Coulombic efficiency in each cycle. Cs ions facilitate efficient interlayer diffusion of Li ions by enlarging the interlayer distance of MLG and also assists further for suppression of Li dendrite growth by electrostatic repulsion against Li ions. When paired with a stable sulfur−carbon composite electrode as a high capacity cathode, the Li−sulfur cell delivers an areal capacity of 4.0 mAh cm −2 , a value comparable to those of current commercial lithium ion batteries, with 81.0% capacity retention after 200 cycles.
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