We report on the experimental observation of a new type of polarization-locked vector soliton in a passively mode-locked fiber laser. The vector soliton is characterized by the fact that not only are the two orthogonally polarized soliton components phase-locked, but also one of the components has a double-humped intensity profile. Multiple phase-locked high-order vector solitons with identical soliton parameters and harmonic mode locking of the vector solitons were also obtained in the laser. Numerical simulations confirmed the existence of stable high-order vector solitons in the fiber laser.

We report on the generation of 281.2 nJ mode locked pulses directly from an erbium-doped fiber laser mode-locked with the nonlinear polarization rotation technique. We show that apart from the conventional dissipative soliton operation, an all-normal-dispersion fiber laser can also emit square-profile dissipative solitons whose energy could increase to a very large value without pulse breaking.

Background Voltage-gated Na+ channels (Nav) are essential for myocyte membrane excitability and cardiac function. Nav current (INa) is a large amplitude, short duration “spike” generated by rapid channel activation followed immediately by inactivation. However, even under normal conditions, a small “late” component of INa (INa,L) persists due to incomplete/failed inactivation of a subpopulation of channels. Notably, INa,L is directly linked with both congenital and acquired disease states. The multifunctional Ca2+/calmodulin-dependent kinase II (CaMKII) has been identified as an important activator of INa,L in disease. Several potential CaMKII phosphorylation sites have been discovered, including Ser571 in the Nav1.5 DI-DII linker, but the molecular mechanism underlying CaMKII-dependent regulation of INa,L in vivo remains unknown. Methods and Results To determine the in vivo role of Ser571, two Scn5a knock-in mouse models were generated expressing either: 1) Nav1.5 with a phosphomimetic mutation at Ser571 (S571E), or 2) Nav1.5 with the phosphorylation site ablated (S571A). Electrophysiology studies revealed that Ser571 regulates INa,L but not other channel properties previously linked to CaMKII. Ser571-mediated increases in INa,L promote abnormal repolarization and intracellular Ca2+ handling, and increase susceptibility to arrhythmia at the cellular and animal level. Importantly, Ser571 is required for maladaptive remodeling and arrhythmias in response to pressure overload. Conclusions Our data provide the first in vivo evidence for the molecular mechanism underlying CaMKII activation of the pathogenic INa,L. Relevant for improved rational design of potential therapies, our findings demonstrate that Ser571-dependent regulation of Nav1.5 specifically tunes INa,L without altering critical physiological components of the current.

Mode locking of an ytterbium-doped fiber laser with atomic multilayer graphene is, to the best of our knowledge, experimentally demonstrated for the first time. Dissipative solitons with duration of 580 ps at 1069.8 nm were generated. Since graphene can also be used to mode lock erbium-doped fiber lasers, our result shows that graphene indeed has wavelength-independent saturable absorption, which could be exploited to mode lock fiber lasers with various operating wavelengths.

We report on the generation of multi-wavelength dissipative soliton (DS) in an all normal dispersion fiber laser passively mode-locked with a semiconductor saturable absorber mirror (SESAM). We show that depending on the strength of the cavity birefringence, stable single-, dual- and triple-wavelength DSs can be formed in the laser. The multi-wavelength soliton operation of the laser was experimentally investigated, and the formation mechanisms of the multi-wavelength DSs are discussed.

We report on the dark pulse emission of an all-normal dispersion erbium-doped fiber laser with a polarizer in cavity. We found experimentally that apart from the bright pulse emission, under appropriate conditions the fiber laser could also emit single or multiple dark pulses. Based on numerical simulations we interpret the dark pulse formation in the laser as a result of dark soliton shaping.

These data provide new insight into membrane targeting of TREK-1 in the heart and establish a broader role for β(IV)-spectrin in organizing functional membrane domains critical for normal heart function.

We report on dissipative soliton (DS) generation in an Yb-doped (YDF) fiber laser passively mode locked with the nonlinear polarization rotation (NPR) technique. We found that even without the insertion of a physical bandpass filter in the cavity, not only could DSs be automatically formed in the laser but also the formed DSs have a spectral bandwidth that is far narrower than the Yb-fiber gain bandwidth. Numerical simulations well reproduced the experimental observations. Our results suggest that a physical intracavity bandpass filter is not a crucial component for the generation of DSs in all-normal-dispersion YDF lasers mode locked with the NPR technique.