We report on the generation of 281.2 nJ mode locked pulses directly from an erbium-doped fiber laser mode-locked with the nonlinear polarization rotation technique. We show that apart from the conventional dissipative soliton operation, an all-normal-dispersion fiber laser can also emit square-profile dissipative solitons whose energy could increase to a very large value without pulse breaking.
We report on the experimental evidence of four wave mixing (FWM) between the two polarization components of a vector soliton formed in a passively mode-locked fiber laser. Extra spectral sidebands with out-of-phase intensity variation between the polarization resolved soliton spectra was firstly observed, which was identified to be caused by the energy exchange between the two soliton polarization components. Other features of the FWM spectral sidebands and the soliton internal FWM were also experimentally investigated and numerically confirmed.
Human monocytes can be classified into two subsets with distinctive characteristics. In this study, we report a difference in apoptotic potential between these two subsets with CD14+/lowCD16+ monocytes being more susceptible than CD14+CD16− monocytes to undergo spontaneous apoptosis and apoptosis induced by reactive oxygen species (ROS). By global transcriptomic and proteomic approaches, we observed that CD14+/lowCD16+ monocytes expressed higher levels of pro-apoptotic genes and proteins such as TNFα, caspase 3, Bax and cytochrome c and showed more caspases 3 and 7 activities. They also exhibited greater aerobic respiration resulting in a higher production of ROS from the mitochondria. CD14+CD16− monocytes, in contrast, showed higher expression of glutathione (GSH)-metabolizing genes such as GSH peroxidase and microsomal GSH S-transferase and were more resistant to oxidative stress than CD14+/lowCD16+ monocytes. The apoptosis of CD14+/lowCD16+ monocytes was ROS dependent as reducing ROS levels significantly reduced cell death. This is the first report of a differential apoptotic propensity of human monocyte subsets, and gaining a better understanding of this process may help to provide a better understanding of the roles of these subsets during homeostasis and under pathological conditions, particularly in situations in which high levels of oxidants are present.
We report on the dissipative soliton (DS) trapping in a fiber ring laser mode locked with a semiconductor saturable absorber mirror and operated in normal dispersion regime. It was shown that despite the fact that a DS is strongly frequency chirped, two DSs formed along the two orthogonal polarization directions of a birefringent cavity fiber laser can incoherently couple and travel with the same group velocity in the laser. Numerical simulations have well confirmed the experimental observations.
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