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Three novel quinic acid esters, i.e., neochlorogenic acid methyl ester (1), cryptochlorogenic acid methyl ester (2), and chlorogenic acid methyl ester (3), were isolated from Viburnum cylindricum. Their structures were determined by spectroscopic analysis. Viburnum cylindricum is distributed in tropical Asia, which has been used as folk medicine to treat different diseases, such as cough, diarrhea, rheumatoid arthritis, and tumefaction [8]. A literature search revealed that no previous phytochemical and pharmacological study has been undertaken of this species. As part of ongoing phytochemical and pharmacological investigations of the genus Viburnum, we collected the stems and leaves of V. cylindricum from Kunming in Yunnan province. From the AcOEt extract, three new quinic acid esters besides several known compounds were isolated: neochlorogenic acid methyl ester 1 ) (1), cryptochlorogenic acid methyl ester

Undaria pinnatifida sporophyll (U. pinnatifida) is a major byproduct of U. pinnatifida (a brown algae) processing. Its phenolic constituents, phlorotannins, are of special interest due to their intrinsic ability to precipitate proteins. Herein, a high-temperature extraction procedure was used to isolate these biologically active compounds. The heating temperature, heating time, and extraction solvent (ethanol) concentration were examined with response surface analysis to determine the optimal conditions to achieve the maximum extraction rate. The analysis revealed the optimal conditions to be: 170 °C of heating temperature, 5.2 h of heating time, and 52% ethanol concentration for a yield of 10.7 ± 0.2 mg gallic acid equivalent/g dry weight (GAE/g DW) of sample. Compared to epigallocatechin gallate (EGCG), the extracted phlorotannins displayed higher antioxidant activity on H2O2-induced RAW 264.7 cells with improved efficiency. Furthermore, the compounds exhibited strong anti-inflammatory activity. These findings potentially can be utilized to guide development of novel functional foods and food supplements from sea-originated resources such as brown algae.

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