The avascular microscopic breast and brain tumors (<1-2 mm diameter) can be noninvasively detected by designing human heavy-chain ferritin (HFn)-based nanoparticles as molecular probes for near-infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn-based nano-particles (Cy5.5-HFn and M-HFn) can cross the endothelium, epithelium, and blood-brain barriers and be internalized into tumor cells.

The East Asian summer monsoon affects precipitation and hence vegetation in the densely populated Northwest Pacific region, yet a long-standing controversy exists concerning the spatial and temporal dynamics of the Holocene Optimum (HO) in the East Asian Monsoon Region. Here we use a detailed 14,000-year record reconstructing vegetation variations from a strategically selected crater lake from Northeast China, as well as a compilation of previous paleoclimatic studies, to show that the HO began around 6,000 Cal a BP in Northeast China, significantly later than generally recognized. By comparing our paleoenvironmental data with Holocene vegetation records from other regions of East Asia, we identified a marked northward shift for the onset of the HO from ~10,260 Cal a BP in South China to ~6,000 Cal a BP in Northeast China. The gradual northward transgression of the vegetation change could be caused by both the temperature and precipitation changes in different regions. Finally, we fitted a regression model of the start of the HO period versus latitude, which allowed us to make predictions for the beginning of the HO based at different geographical locations. This study reveals a strong relationship between latitude and the initiation of the HO, and provides a window towards better understanding the forcing of vegetation changes in the East Asian monsoon region.

User search query logs have proven to be very useful, but have vast potential for misuse. Several incidents have shown that simple removal of identifiers is insufficient to protect the identity of users. Publishing such inadequately anonymized data can cause severe breach of privacy. While significant effort has been expended on coming up with anonymity models and techniques for microdata, there is little corresponding work for query log data. Query logs are different in several important aspects, such as the diversity of queries and the causes of privacy breach. This necessitates the need to design privacy models and techniques specific to this environment. This paper takes a first cut at tackling this challenge. Our main contribution is to define effective anonymization models for query log data along with proposing techniques to achieve such anonymization. We analyze the inherent utility and privacy tradeoff, and experimentally validate the performance of our techniques.

To investigate chromium diffusion kinetics in ultramafic cumulate minerals, we analyzed the Cr elemental and isotopic compositions of olivine, orthopyroxene, and chromite from the Stillwater layered intrusion. Core-to-rim compositional profiles reveal that Cr elemental concentrations decrease from 60 to 20 ppm in olivine and from 5000-4600 to 2700-2400 ppm in orthopyroxene. These zoned Cr distributions in olivine and orthopyroxene suggest that Cr was lost by diffusion into the melt. Olivine and orthopyroxene have d 53 Cr values ranging from-0.09 to 0.25‰ and from-0.11 to 0.07‰, respectively, higher than the values of coexisting chromite (-0.23 to-0.07‰). This isotopic disequilibrium can be explained by diffusion-driven kinetic fractionation during cooling. The preferential diffusion of light Cr isotopes from silicate minerals to the melt resulted in isotopically heavier olivine and orthopyroxene, but the kinetic diffusion between chromite and melt negligibly affected the isotopic compositions of chromite grains due to their high Cr concentrations. Modeling results based on the observed Cr contents and isotopic compositions of silicate minerals constrain the cooling time of the Peridotite Zone in the Stillwater magmatic system to have been 10-100 kyr.