In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.
Amorphous copolymers with rigid azobenzene and ester side groups
form films in which
birefringence can be induced using linearly polarized light. When
both the azobenzene and the ester
groups are polar, cooperative motion occurs and high levels of
birefringence can be achieved at relatively
low azobenzene content. With less polar ester groups, this
cooperative motion is significantly reduced,
suggesting that the effect is not dictated by steric factors (as is the
case in liquid crystalline copolymers),
but by electric interaction between the side group dipoles. The
differences in cooperative motion of two
copolymer systems:
poly{4‘-[(2-(methacryloyloxy)ethyl)ethylamino]-4-nitroazobenzene
(DR1M)-co-4-nitrophenyl
4-[[2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl]oxy]benzoate
(BEM)} (a polar azo/polar ester pair),
and poly{DR1M-co-4-phenyl
4-[[2-[2-(2-methyl-1-oxo-2-propenyl)oxy]ethyl]oxy]benzoate
(NBEM)} (a polar
azo/less polar ester) have been investigated using birefringence
measurements and time dependent infrared
spectroscopy. Thus, the “molecular addressing” concept
introduced by Anderle and Wendorff for liquid
crystalline copolymers is real. Kinetic analysis using
time-dependent infrared spectroscopy clearly shows
that the azobenzene groups move first and are followed by the ester
groups, which move to a much greater
degree when they have similar polarity (BEM with DR1M).
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