NIR‐Laser‐Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors

Meng, Zhouqi; Fang, Wei; Wang, Ronghua; Meng, Xiaorong; Chen, Zhigang; Wang, Huiping; Zhu, Meifang

doi:10.1002/adma.201502669

Cited by 235 publications

(135 citation statements)

References 49 publications

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“…[7][8][9] Among various combination therapies, the combination of PTT with chemotherapy has showed a superior treatment effect in case of prostate cancer. 10,11 PTT usually utilizes near-infrared (NIR) lightabsorbing photosensitizers to damage tumor cells with laser irradiation by heating. 12 However, both photosensitizers and chemotherapeutic agents lack tumor-targeted accumulation and can be easily eliminated from the body.…”

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confidence: 99%

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Lian

et al. 2017

IJN

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Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation. Herein, simple multifunctional nanoparticles (NPs) using IR780 (a near-infrared dye) and docetaxel (DTX)-loaded nanoplatform based on human serum albumin (HSA) (HSA@IR780@DTX) was developed for targeted imaging and for PTT/PDT with chemotherapy for the treatment of castration-resistant prostate cancer treatment. In this platform, HSA is a biocompatible nanocarrier that binds to both DTX and IR780. DTX and IR780, as hydrophobic drug, can induce the self-assembly of HSA proteins. Transmission electron microscopic imaging showed that NPs formed by self-assembly are spherical with a smooth surface with a hydrodynamic diameter of 146.5±10.8 nm. The cytotoxicity of HSA@IR780@DTX NPs with or without laser irradiation in prostate cancer cells (22RV1) was determined via CCK-8 assay. The antitumor effect of HSA@IR780@DTX plus laser irradiation was better than either HSA@IR780@DTX without laser exposure or single PTT heating induced by HSA@IR780 NPs under near-infrared laser, suggesting a significant combined effect in comparison to monotherapy. Near-infrared fluorescence imaging showed that HSA@IR780@DTX NPs could preferentially accumulate in tumors. In vivo therapeutic efficacy experiment showed that xenografted prostate tumors on mice treated with HSA@IR780@DTX plus near-infrared laser irradiation were completely inhibited, whereas tumors on mice treated with chemotherapy alone (HSA@DTX and HSA@IR780@DTX without laser) or PTT/PDT alone (HSA@IR780 with laser) showed moderate growth inhibition. Overall, HSA@IR780@DTX NPs showed notable targeting and theranostic potential for the treatment of castration-resistant prostate cancer.

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confidence: 99%

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Lian

et al. 2017

IJN

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“…Such locally produced heat can induce significant temperature increase in the pathological regions, which thus lead to rapid drug release from the carriers. Recently, numerous photo-to-heat transducers, including AuNPs 108, CuS 109, MoS 2 110, carbon-based nanomaterials 111 and some hybrid nanostructures (e. g. Au-Ag NPs 112, Silica-Au NPs 113, Graphene oxide (GO)-Au nanorods 114, GO-silica 115, etc), have been widely fabricated for the heat induced drug delivery. More importantly, several functional materials, including polymer 116, liposomes 117 and biomolecues 118 etc, have also been reported to endow these novel nanomaterials with desired properties.…”

Section: Near-infrared (Nir) Light-mediated Theranosticsmentioning

confidence: 99%

Recent Advances of Light-Mediated Theranostics

Ai¹,

Mu²,

Xing³

2016

Theranostics

185

121

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Currently, precision theranostics have been extensively demanded for the effective treatment of various human diseases. Currently, efficient therapy at the targeted disease areas still remains challenging since most available drug molecules lack of selectivity to the pathological sites. Among different approaches, light-mediated therapeutic strategy has recently emerged as a promising and powerful tool to precisely control the activation of therapeutic reagents and imaging probes in vitro and in vivo, mostly attributed to its unique properties including minimally invasive capability and highly spatiotemporal resolution. Although it has achieved initial success, the conventional strategies for light-mediated theranostics are mostly based on the light with short wavelength (e.g., UV or visible light), which may usually suffer from several undesired drawbacks, such as limited tissue penetration depth, unavoidable light absorption/scattering and potential phototoxicity to healthy tissues, etc. Therefore, a near-infrared (NIR) light-mediated approach on the basis of long-wavelength light (700-1000 nm) irradiation, which displays deep-tissue penetration, minimized photo-damage and low autofluoresence in living systems, has been proposed as an inspiring alternative for precisely phototherapeutic applications in the last decades. Despite numerous NIR light-responsive molecules have been currently proposed for clinical applications, several inherent drawbacks, such as troublesome synthetic procedures, low water solubility and limited accumulation abilities in targeted areas, heavily restrict their applications in deep-tissue therapeutic and imaging studies. Thanks to the amazing properties of several nanomaterials with large extinction coefficient in the NIR region, the construction of NIR light responsive nanoplatforms with multifunctions have become promising approaches for deep-seated diseases diagnosis and therapy. In this review, we summarized various light-triggered theranostic strategies and introduced their great advances in biomedical applications in recent years. Moreover, some other promising light-assisted techniques, such as photoacoustic and Cerenkov radiation, were also systemically discussed. Finally, the potential challenges and future perspectives for light-mediated deep-tissue diagnosis and therapeutics were proposed.

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“…[1] Different from their counterparts for sustained release, the smart systems typically exhibit fast responses to a variety of stimuli, including light, [2] temperature, [3] ultrasound, [4] pH, [5] mechanical stress, [6] and specific biomolecules. [7] Among the various types of stimuli, light is especially attractive because it can be remotely applied with high spatial and temporal resolutions.…”

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confidence: 99%

A Eutectic Mixture of Natural Fatty Acids Can Serve as the Gating Material for Near‐Infrared‐Triggered Drug Release

et al. 2017

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A smart release system responsive to near-infrared (NIR) light has been developed for intracellular drug delivery. We demonstrate the concept by co-encapsulating doxorubicin (DOX, an anticancer drug) and IR780 iodide (IR780, a NIR-absorbing dye) into nanoparticles made of a eutectic mixture of naturally occurring fatty acids. The eutectic mixture has a well-defined melting point at 39 °C, which can be used as a biocompatible phase-change material for NIR-triggered drug release. The resultant nanoparticles exhibit prominent photothermal effect and quick drug release in response to NIR irradiation. Fluorescence microscopy analysis indicates that the DOX trapped in the nanoparticles can be efficiently released into the cytosol under NIR irradiation, resulting in enhanced anticancer activity. This work offers a new platform for designing effective intracellular drug release systems, holding great promise for future cancer therapy.

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NIR‐Laser‐Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors

Cited by 235 publications

References 49 publications

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Self-assembled albumin nanoparticles for combination therapy in prostate cancer

Recent Advances of Light-Mediated Theranostics

A Eutectic Mixture of Natural Fatty Acids Can Serve as the Gating Material for Near‐Infrared‐Triggered Drug Release

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