In this study, thermoresponsive and mussel-inspired polypeptides were synthesized using ring-opening polymerization of α-amino acid derivatives of N-carboxyanhydride (NCA). The tissue adhesive properties of these polypeptides were evaluated using in vitro adhesive strength tests on porcine skin and bone. The results indicated that the species of the functional polypeptide side groups and the adhesive temperature have a significant influence on the adhesion strength. The maximum of the lap-shear adhesion strength on porcine skin was 101.2 kPa, and the maximum of tensile adhesion strength on bone was 603 kPa. The in vivo antibleeding activity and tissue adhesive ability were also evaluated using a rat model. These polypeptides exhibited superior hemostatic properties and healing effects in the skin incision and osteotomy gap, and the skin incision healing and osteotomy gap remodeling were completed in all rats after 2–9 weeks. These polypeptides are expected to be good candidates for surgical tissue adhesives, tissue engineering materials, and antibleeding materials, etc.

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A series of reversible triblock poly(amino acid)s hydrogels with tunable pH‐responsivity (pH 3.5–10.0) were synthesized by adjusting the ratio of the blocks. Attributing to the good biodegradability and low cytotoxicity of these triblock poly(amino acid)s, it is obvious that these poly(amino acid)s are potential novel materials in drug delivery and injectable hydrogels.

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