Versatile Surgical Adhesive and Hemostatic Materials: Synthesis, Properties, and Application of Thermoresponsive Polypeptides

Lu, Dedai; Wang, Hongsen; Li, Tingʹe; Li, Yunfei; Wang, Xiangya; Niu, Pengfei; Guo, Hongyun; Sun, Shuhan; Wang, Xiaoqi; Guan, Xiaolin; Ma, Hengchang; Lei, Ziqiang

doi:10.1021/acs.chemmater.7b00255

Cited by 48 publications

(41 citation statements)

References 81 publications

(131 reference statements)

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“…Thus, the mass of formazan is proportional to the number of living cells. 49 The absorbance of the dimethyl sulfoxide solution with formazan is determined by microplate microscopy. The cytotoxicity of QCT–TTO–pADM is determined by an MTT assay.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Wang

Gong

et al. 2020

ACS Omega

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Infection is a common complication in the process of wound management. An ideal wound dressing is supposed to reduce or even prevent the infection while promoting wound healing. A porcine acellular dermal matrix (pADM) has been already used as a wound dressing in clinic due to its capacity to accelerate wound healing. However, not only is pure pADM not antibacterial, its mechanical properties are poor. In this study, an antibacterial pADM with good performance was prepared by adding two natural products as modifiers, quercetin (QCT) and tea tree oil (TTO). The result of Fourier-transform infrared (FTIR) proved that the addition of modifiers did not break the natural triple-helical structure of collagen. Meanwhile, the results of differential scanning calorimetry (DSC), thermogravimetric analysis (TG), mechanic experiment, and enzymatic degradation demonstrated that pADM handled with QCT and TTO (termed QCT–TTO–pADM) had better thermal stability, mechanical strength, and resistance to enzymatic degradation than pADM. Meanwhile, QCT–TTO–pADM had excellent antibacterial activity and showed an antibacterial rate of over 80%. Furthermore, in the cytocompatibility analysis, QCT–TTO–pADM had no side effects on the adhesion, growth, and proliferation of fibroblasts. QCT–TTO–pADM could even accelerate wound healing more efficiently than pADM and glutaraldehyde-modified pADM (GA-pADM). In conclusion, QCT–TTO–pADM was a potential antibacterial wound dressing with good performance.

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Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Wang

Gong

et al. 2020

ACS Omega

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“…When heated above LCST, p(NIPAAm) becomes hydrophobic allowing catechol to be exposed for adhesion. Bioadhesive based on thermoresponsive peptide consisting of polyglutamic acid functionalized with oligomeric diethylene glycol monomethyl ether (poly(EG 2 ‐Glu)) exhibited enhanced adhesion at body temperature as compared to results obtained at room temperature . This increase in measure adhesive property is due to an increased in the cohesive property of poly(EG 2 ‐Glu) at body temperature.…”

Section: Multifunctional Biomedical Adhesivesmentioning

confidence: 98%

Multifunctional Biomedical Adhesives

Pinnaratip

Bhuiyan

Meyers

et al. 2019

Adv Healthcare Materials

143

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Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self‐healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.

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“…The intact cell monolayer can be successfully obtained on the thermoresponsive cell culture dish [83]. Lu et al synthesized a series of thermoresponsive polypeptides incorporated with various functional side groups [84]. They found that the polypeptides showed excellent biodegradability, biocompatibility, and mechanical properties in in vitro adhesion tests with no cytotoxicity.…”

Section: Applicationsmentioning

confidence: 99%

Thermoresponsive Polypeptoids

Liu

Sun

2020

Polymers

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Stimuli-responsive polymers have been widely studied in many applications such as biomedicine, nanotechnology, and catalysis. Temperature is one of the most commonly used external triggers, which can be highly controlled with excellent reversibility. Thermoresponsive polymers exhibiting a reversible phase transition in a controlled manner to temperature are a promising class of smart polymers that have been widely studied. The phase transition behavior can be tuned by polymer architectures, chain-end, and various functional groups. Particularly, thermoresponsive polypeptoid is a type of promising material that has drawn growing interest because of its excellent biocompatibility, biodegradability, and bioactivity. This paper summarizes the recent advances of thermoresponsive polypeptoids, including the synthetic methods and functional groups as well as their applications.

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Versatile Surgical Adhesive and Hemostatic Materials: Synthesis, Properties, and Application of Thermoresponsive Polypeptides

Cited by 48 publications

References 81 publications

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Preparation and Characterization of Antibacterial Porcine Acellular Dermal Matrices with High Performance

Multifunctional Biomedical Adhesives

Thermoresponsive Polypeptoids

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