Preparation and properties of reversible hydrogels based on triblock poly(amino acid)s with tunable pH‐responsivity across a broad range

Abstract

A series of reversible triblock poly(amino acid)s hydrogels with tunable pH‐responsivity (pH 3.5–10.0) were synthesized by adjusting the ratio of the blocks. Attributing to the good biodegradability and low cytotoxicity of these triblock poly(amino acid)s, it is obvious that these poly(amino acid)s are potential novel materials in drug delivery and injectable hydrogels.

Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s

“…The enzyme degradation reaction was used to measure the degradation property of HPTTG . As shown in Figure C, under the action of the protemax, the mass loss of HPTTG-6.8 was more than 70% after 18 days.…”

“…When the pH value of the HPTTG solution decreases, the carboxyl groups and the phenolic hydroxyl groups are deionized; intramolecular hydrogen bonds are formed. 40 The chain of HPTTG is shrunk, and the HPTTG segment, being a hydrophilic segment, allows it to wrap water molecules to form a hydrogel. The p K a value of the acidic or basic groups leads to the pH response changes of poly(amino acid)s, such as poly( l -glutamic acid) (p K a 4.1) and poly( l -tyrosine) (p K a 10.0).…”

“…When the pH value of the solution is above the p K a of carboxyl groups and phenolic hydroxyl groups, the carboxyl groups and the phenolic hydroxyl groups are ionized. When the pH value of the HPTTG solution decreases, the carboxyl groups and the phenolic hydroxyl groups are deionized; intramolecular hydrogen bonds are formed . The chain of HPTTG is shrunk, and the HPTTG segment, being a hydrophilic segment, allows it to wrap water molecules to form a hydrogel.…”

Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

“…The discovery and design of stimulus-sensitive agents according to the differences of pH and redox potential between normal cells and tumor cells has been extensively explored in recent years [ 4 , 5 , 6 , 7 ]. Tumor cells are found to overproduce intracellular glutathione (GSH) or reactive oxygen species (ROS) to maintain a strongly reducing environment or increased oxidative stress.…”

Σύνθεση Αποκρίσιμων Πολυμερών Για Τον Εγκλωβισμό Και Μεταφορά Φαρμάκων Για Τον Καρκίνο Του Παγκρέατος

“…Υπό αυτές τις συνθήκες, επιβεβαιώθηκε επίσης με SEM ότι η πορώδης μικροδομή των γελών με οργανικό διαλύτη παρέμεινε, η οποία διατήρησε 87 φορές το ξηρό βάρος τους σε νερό. Λόγω της pH-ανταπόκρισης του PLG, το οποίο σχηματίζει α-έλικες κάτω από pH 6 και υιοθετεί τυχαία σπειράματα σε pH 10, τα υδροπήγματα διογκώθηκαν σε pH 10 και συρρικνώθηκαν σε pΗ 4.Περαιτέρω έρευνα στον τομέα των υδρογελών πραγματοποιήθηκε από τους Lu και άλλους[41] οι οποίοι σχεδίασαν μια σειρά πολυπεπτιδίων τριών συστάδων τύπου ΑΒΑ με αποκρισιμότητα στο pΗ. Οι τρεις-συστάδες…”