Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s

Lu, Dedai; Wang, Jiachen; Li, Yunfei; Zhang, Yongyong; Yu, Lili; Guo, Hongyun; Zhang, Yongdong; Wang, Xingdong; Wang, Xiaoqi; Teng, Gao‐Jun; Lei, Ziqiang

doi:10.1021/acscentsci.0c00506

Cited by 21 publications

(19 citation statements)

References 56 publications

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“…A change with the composition and concentration of solution buffer can result in a fluctuation in the dielectric permittivity of medium, and thus change the magnitude of van der Waals interactions. Such efforts on environment‐dependence of interpeptide interactions should be rigorously pursued in future efforts for developing peptide‐enabled delivery systems towards tumor microenvironments 35–37 …”

Section: Resultsmentioning

confidence: 99%

Composition‐dependent multivalency of peptide–peptide interactions revealed by tryptophan‐scanning mutagenesis

Zheng

Fang

et al. 2021

Journal of Peptide Science

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We have examined in this contribution the composition dependence of binding characteristics in peptide–peptide interactions between an oligopeptide octa‐glycine and a series of tryptophan‐containing octapeptides. The binding energy associated with tryptophan–glycine interactions manifests pronounced stepwise binding characteristics as the number of tryptophan increases from 0 to 8 in the octapeptides consisting only of glycine and can be attributed to mono‐, di‐, and tri‐valent peptide–peptide interactions. At the same time, only weak fluctuations in binding energy were observed as the number of tryptophan increases from 2 to 7. Such distinctive nonlinearity of composition‐dependent tryptophan–glycine binding energy characteristics due to continuously varying tryptophan compositions in the octapeptides could be considered as a reflection of combinatorial contributions due to the hydrogen bonds originated from the indole moieties of tryptophan with the main chains of octapeptide of glycine containing N–H and C=O moieties and the van der Waals interactions (including π–π and π–CH interactions) between peptides.

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Section: Resultsmentioning

confidence: 99%

Composition‐dependent multivalency of peptide–peptide interactions revealed by tryptophan‐scanning mutagenesis

Zheng

Fang

et al. 2021

Journal of Peptide Science

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“…In addition to the abovementioned materials, pH-responsive polymers can also be used as embolic materials [ 80 , 81 ]. When an aqueous solution of a polymer embolic agent whose responsive pH value is similar to or the same as the pH of the acidic TME is injected into the tumor site, the polymer solution will change from sol to gel as the pH of the tumor tissue decreases, thereby blocking the tumor blood vessels and achieving the purpose of tumor growth inhibition.…”

Section: Tumor Microenvironment-responsive Nanoparticles For Emboliza...mentioning

confidence: 99%

Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy

Dong

Yang

et al. 2022

J Nanobiotechnol

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Tumor embolization therapy has attracted great attention due to its high efficiency in inhibiting tumor growth by cutting off tumor nutrition and oxygen supply by the embolic agent. Although transcatheter arterial embolization (TAE) is the mainstream technique in the clinic, there are still some limitations to be considered, especially the existence of high risks and complications. Recently, nanomaterials have drawn wide attention in disease diagnosis, drug delivery, and new types of therapies, such as photothermal therapy and photodynamic therapy, owing to their unique optical, thermal, convertible and in vivo transport properties. Furthermore, the utilization of nanoplatforms in tumor non-interventional embolization therapy has attracted the attention of researchers. Herein, the recent advances in this area are summarized in this review, which revealed three different types of nanoparticle strategies: (1) nanoparticles with active targeting effects or stimuli responsiveness (ultrasound and photothermal) for the safe delivery and responsive release of thrombin; (2) tumor microenvironment (copper and phosphate, acidity and GSH/H2O2)-responsive nanoparticles for embolization therapy with high specificity; and (3) peptide-based nanoparticles with mimic functions and excellent biocompatibility for tumor embolization therapy. The benefits and limitations of each kind of nanoparticle in tumor non-interventional embolization therapy will be highlighted. Investigations of nanoplatforms are undoubtedly of great significance, and some advanced nanoplatform systems have arrived at a new height and show potential applications in practical applications.

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“…This means that the decrease in pH triggers the sol-to-gel transition and formation of a 3D gel network. Another pH-responsive hydrogel is hyperbranched poly(amino acid) (HPTTG), developed for noninvasive target embolization ( Figure 5 A) [ 129 ]. The sol–gel transition with reducing pH of HPTTG was regulated by adjusting the acidic amino acids in copolymers ( Figure 5 B).…”

Section: Polymer-based Embolic Agentsmentioning

confidence: 99%

Emerging Polymer Materials in Trackable Endovascular Embolization and Cell Delivery: From Hype to Hope

Rana

Melancon

2022

Biomimetics

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Minimally invasive endovascular embolization is a widely used clinical technique used for the occlusion of blood vessels to treat various diseases. Different occlusive agents ranging from gelatin foam to synthetic polymers such as poly(vinyl alcohol) (PVA) have been commercially used for embolization. However, these agents have some drawbacks, such as undesired toxicity and unintended and uncontrolled occlusion. To overcome these issues, several polymer-based embolic systems are under investigation including biocompatible and biodegradable microspheres, gelling liquid embolic with controlled occlusive features, and trackable microspheres with enhanced safety profiles. This review aims to summarize recent advances in current and emerging polymeric materials as embolization agents with varying material architectures. Furthermore, this review also explores the potential of combining injectable embolic agents and cell therapy to achieve more effective embolization with the promise of outstanding results in treating various devastating diseases. Finally, limitations and challenges in developing next-generation multifunctional embolic agents are discussed to promote advancement in this emerging field.

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Tumor Noninvasive and Target Embolization Therapy Platform by Intravenous Injection Based on Acidic Microenvironment-Responsive Hyperbranched Poly(amino acid)s

Cited by 21 publications

References 56 publications

Composition‐dependent multivalency of peptide–peptide interactions revealed by tryptophan‐scanning mutagenesis

Composition‐dependent multivalency of peptide–peptide interactions revealed by tryptophan‐scanning mutagenesis

Recent advances in smart nanoplatforms for tumor non-interventional embolization therapy

Emerging Polymer Materials in Trackable Endovascular Embolization and Cell Delivery: From Hype to Hope

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