The results demonstrated that FA-CUR-NLCs were efficient in selective delivery to cancer cells over-expressing FA receptors (FRs). Also FA-CUR-NLCs transfer CUR to the breast cancer cells, enhance the anti-tumor capacity. Thus, FA-CUR-NLCs could prove to be a superior nanomedicine to achieve tumor therapeutic efficacy.

Context: Breast cancer is the most common cancer in female population. Breast cancer chemotherapy using doxorubicin (DOX) is well illustrated. However, a significant obstacle for successful chemotherapy with DOX is multidrug resistant (MDR) in breast cancer cells. Targeted nanocarriers have emerged as frontier research for the improvement of cancer chemotherapy. Objective: Bombesin (Bn)-modified, DOX-loaded solid lipid nanoparticles (Bn-DOX/SLNs) were constructed. Doxorubicin-resistant MCF-7/MDR human breast cancer cells and the cancer animal models were applied for the evaluation of the in vitro and in vivo anti-tumor effect of Bn-DOX/SLNs. Methods: Bn-conjugated lipids were synthesized. DOX was then loaded into Bn-modified SLNs. The physicochemical properties of the Bn-DOX/SLNs were investigated by particle size and zeta potential measurement, drug loading and drug-entrapment efficiency, and in vitro drug release behavior. In vitro cytotoxicity against MCF-7/MDR cells was investigated, and in vivo anti-tumor of SLNs was evaluated in human breast cancer mice models. Results: Bn-DOX/SLNs showed an excellent in vitro cytotoxicity and in vivo anti-tumor effect both in MCF-7/MDR breast cancer cells and breast cancer animal model. Conclusion:The results demonstrated that Bn-DOX/SLNs reversed the resistance of doxorubicin, suggesting that chemotherapy using this kind of targeted nanocarriers may benefit human breast MDR cancer therapy.

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Objective. To explore the application value of health education combined with aerobic exercise in patients with mastitis found in physical examination. Methods. The clinical data of 100 patients with mastitis who underwent physical examination in the physical examination center of our hospital from October 2020 to October 2021 were retrospectively analyzed. According to the order of physical examination, they were equally split into experimental group and control group. The control group received the routine clinical intervention, while the experimental group received health education combined with aerobic exercise to evaluate the clinical effects of different intervention modes on patients with mastitis. Results. Compared with the control group, the experimental group after intervention achieved notably higher scores of CD-RISC, self-management ability, and mastitis-related knowledge ( P < 0.001 ), lower scores of breast pain, skin color, and local mass diameter ( P < 0.001 ), and a higher SF-36 score ( P < 0.001 ). Conclusion. The clinical intervention combining health education with aerobic exercise in patients with mastitis found in the physical examination is an effective method to improve their mood state and self-management ability, and further research will help provide a good solution for such patients.