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The protection of retinal pigment epithelium (RPE) injury plays an important role in the prevention of or in delaying the pathological progress of retinal degeneration diseases, like age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa. Oxidative stress has been identified as a major inducer of RPE injury, which eventually could lead to a loss of vision. Kaempferol is a natural flavonoid widely distributed in many edible plants, fruits, and traditional medicines and has been reported to have antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. The present study demonstrates that the total antioxidant capacity of kaempferol is approximately two times stronger than that of lutein which is also a natural antioxidant that is widely used in the prevention or treatment of AMD. Our data indicates that kaempferol protects human RPE cells (ARPE-19) from hydrogen peroxide- (H2O2-) induced oxidative cell damage and apoptosis through the signaling pathways involving Bax/Bcl-2 and caspase-3 molecules proofed by real-time PCR and Western blot results. Kaempferol also inhibits the upregulated vascular endothelial growth factor (VEGF) mRNA expression levels induced by H2O2 in ARPE-19 cells and affects the oxidation and antioxidant imbalanced system in ARPE-19 cells treated by H2O2 through the regulations of both the activities of reactive oxygen species (ROS) and superoxide dismutase (SOD). Furthermore, our in vivo experimental results show that in sodium iodate-induced retinal degeneration rat model, kaempferol could protect sodium iodate-induced pathological changes of retina tissue and retinal cells apoptosis as well as the upregulated VEGF protein expression in RPE cells. In summary, these novel findings demonstrate that kaempferol could protect oxidative stressed-human RPE cell damage through its antioxidant activity and antiapoptosis function, suggesting that kaempferol has a potential role in the prevention and therapeutic treatment of AMD or other retinal diseases mediated by oxidative stress.

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This paper presents a new lumped-parameter model for describing the dynamics of vapor compression cycles. In particular, the dynamics associated with the two heat exchangers, i.e., the evaporator and the condenser, are modeled based on a moving-interface approach by which the position of the two-phase/single-phase interface inside the one-dimensional heat exchanger can be properly predicted. This interface information has never been included in previous lumped-parameter models developed for control design purpose, although it is essential in predicting the refrigerant superheat or subcool value. This model relates critical performance outputs, such as evaporating pressure, condensing pressure, and the refrigerant superheat, to actuating inputs including compressor speed, fan speed, and expansion valve opening. The dominating dynamic characteristics of the cycle around an operating point is studied based on the linearized model. From the resultant transfer function matrix, an interaction measure based on the Relative Gain Array reveals strong cross-couplings between various input-output pairs, and therefore indicates the inadequacy of independent SISO control techniques. In view of regulating multiple performance outputs in modern heat pumps and air-conditioning systems, this model is highly useful for design of multivariable feedback control.

Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η-bz)Ru(N^N)Cl]PF to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

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Two half-sandwich RuII diimine complexes combine features of bioimaging, anticancer and antimetastasis properties into one molecule. The complexes target mitochondria and damage mitochondrial integrity.

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