Ingenious microstructure design and a suitable multicomponent strategy are still challenging for advanced electromagnetic wave absorbing (EMA) materials with strong absorption and a broad effective absorption bandwidth (EAB) at thin sample thickness and low filling level. Herein, a three-dimensional (3D) dielectric Ti3C2T x MXene/reduced graphene oxide (RGO) aerogel anchored with magnetic Ni nanochains was constructed via a directional-freezing method followed by the hydrazine vapor reduction process. The oriented cell structure and heterogeneous dielectric/magnetic interfaces benefit the superior absorption performance by forming perfect impedance matching, multiple polarizations, and electric/magnetic-coupling effects. Interestingly, the prepared ultralight Ni/MXene/RGO (NiMR-H) aerogel (6.45 mg cm–3) delivers the best EMA performance in reported MXene-based absorbing materials up to now, with a minimal reflection loss (RLmin ) of −75.2 dB (99.999 996% wave absorption) and a broadest EAB of 7.3 GHz. Furthermore, the excellent structural robustness and mechanical properties, as well as the high hydrophobicity and heat insulation performance (close to air), guarantee the stable and durable EMA application of the NiMR-H aerogel to resist deformation, water or humid environments, and high-temperature attacks.

A large-scale carbon nanotube∕CoFe2O4 (CNTs∕CoFe2O4) spinel nanocomposite has been fabricated by a chemical vapor deposition method using CoFe2O4 nanoparticles as catalysts. A uniform mixture of CNTs and CoFe2O4 nanoparticles was obtained simultaneously. The structure and chemical composition of the product were investigated using various techniques, such as x-ray diffraction, high-resolution transmission electron microscopy, and electron energy loss spectroscopy. It was found that the particles functionalized on CNTs were cubic phase CoFe2O4. Microwave absorption of the CNT∕CoFe2O4 nanocomposites at 2–18 GHz is evidently enhanced, as compared with that of both pure CNTs and CoFe2O4 nanoparticles. The enhancement mechanism is discussed based on magnetization hysteresis loop measurement and electromagnetic theory.

High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade serous ovarian cancer (LGSOC). Here, we describe the aggressive nature of HGSOC ascitic tumor cells (ATCs) characterized by integrin α5high (ITGA5high) ATCs, which are prone to forming heterotypic spheroids with fibroblasts. We term these aggregates as metastatic units (MUs) in HGSOC for their advantageous metastatic capacity and active involvement in early peritoneal dissemination. Intriguingly, fibroblasts inside MUs support ATC survival and guide their peritoneal invasion before becoming essential components of the tumor stroma in newly formed metastases. Cancer-associated fibroblasts (CAFs) recruit ITGA5high ATCs to form MUs, which further sustain ATC ITGA5 expression by EGF secretion. Notably, LGSOC is largely devoid of CAFs and the resultant MUs, which might explain its metastatic delay. These findings identify a specialized MU architecture that amplifies the tumor–stroma interaction and promotes transcoelomic metastasis in HGSOC, providing the basis for stromal fibroblast-oriented interventions in hampering OC peritoneal propagation.

FIGURE 4: Effect of aging time on oil recovery by spontaneous imbibition vs. time. FIGURE 5: Oil recovery by spontaneious imbibition vs. dimensionless time.

No abstract

No abstract

There is an urgent need to make cisplatin (cDDP) more effective and less toxic in the treatment of ovarian cancer for its systemic side effects and high resistance rate. In this study, we investigated the effect of quercetin (Qu) pretreatment on the potentiation of cDDP in ovarian cancer. We found that Qu pretreatment significantly enhanced cDDP cytotoxicity in an ovarian cancer cell line and primary cancer cells. In addition, we demonstrated that Qu elicited obvious endoplasmic reticulum stress (ERS) and activated all three branches of ERS in ovarian cancer. Specific inhibitors of each ERS pathway, as well as the general ERS stabilizer tauroursodeoxycholic acid, notably diminished such enhancing effects. Furthermore, Qu notably suppressed STAT3 phosphorylation, leading to downregulation of the BCL-2 gene downstream of STAT3. Moreover, blocking ERS restored the protein levels of phosphorylated STAT3 as well as BCL-2 expression, thus abolishing the chemosensitization potency of Qu; these results revealed that Qu affected the STAT3 pathway to enhance cDDP cytotoxicity, and this effect involved ERS signaling. In a xenograft mouse model of ovarian cancer, Qu enhanced the antitumor effect of cDDP. Tumors from mice treated with cDDP in combination with Qu pretreatment had repressed STAT3 phosphorylation, lower BCL-2 and higher apoptosis levels compared with those from the other groups. Meanwhile, Qu markedly reduced the elevation of blood creatinine during cDDP intervention. These data indicate that Qu pretreatment potentiates the antitumor effects of cDDP in ovarian cancer while protecting the kidneys against damage. Therefore the strategy of Qu pretreatment may be beneficial in enhancing the therapeutic efficacy of cDDP against ovarian cancer.

The authors regret that in their original paper, the Masson's image of the control group in Fig. 7 J was incorrect as a result of an error during figure preparation. The corrected figure appears below.