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ABSTRACT.It is well known that thrombocytopenia is the most commonly acquired haemostatic disorder in dogs and can be potentially life-threatening. With the use of automated analysers, platelet indices such as Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and Platelet Large Cell Ratio (P-LCR), became routinely available, allowing data comparison and error checks which results in a more effective quality control. The aim of this study was to evaluate the pattern of platelet indices (MPV, PDW and P-LCR) in dogs with thrombocytopenia and with normal platelet values. The results of 351 CBCs processed in an automated veterinary haematology counter Sysmex ® pocH-100iV Diff were analysed. Two groups of dogs were established, those with thrombocytopenia (45) and those with normal platelet counts (306). Thrombocytopenic dogs were subdivided in dogs with less than 150,000 platelets/ µL of blood (19/42,2%) and dogs with over 150,000 platelets /µL of blood (26/ 57,8%). Mean values of PDW and P-LCR indices in thrombocytopenic animals were significantly higher than the mean values of animals with normal platelet counts. There was no significant difference in any of the indices in either group of thrombocytopenic dogs. Macroplatelets were present in the blood smears of thrombocytopenic dogs. Results suggested increased thrombopoiesis and release of different sized platelets. It was concluded that both PDW and P-LCR increase in dogs with thrombocytopenia and they are more sensitive than MPV. P-LCR is also important in thrombocytopenic dogs, especially when associated to the presence of large platelets in blood smears.Key words: platelets, anisocytosis, blood cell analyzer, platelet distribution width. RESUMEN.Es conocido que la trombocitopenia es el trastorno hemostático más común de los perros y una potencial amenaza de vida. Utilizando analizadores automatizados, los índices plaquetarios como el Volumen Plaquetario Medio (MPV), la Amplitud de Distribución Plaquetaria (PDW) y el Porcentaje de Plaquetas Grandes (P-LCR) han sido exámenes rutineros, permitiendo comparaciones de datos y verificaciones de errores y, consecuentemente, un mayor control de calidad. El objetivo del estudio consistió en evaluar el patrón de los índices plaquetarios (MPV, PDW y P-LCR ) en perros trombocitopénicos y perros con valores plaquetarios normales. Fueron analizados los resultados de 351 hemogramas procesados en un contador automatizado de hematología veterinaria Sysmex ® pocH-100iV Diff. Los perros fueron divididos entre los trombocitopénicos (45) y aquellos con recuentos plaquetarios normales (306). Se dividieron los perros trombocitopénicos entre los que presentaban menos que 150.000 plaquetas/µL de sangre (19/42,2%) y los que tenían más que 150.000 plaquetas/µL de sangre (26/57,8%). Los promedios de los índices de PDW y P-LCR en los trombocitopénicos fueron significativamente mayores que aquellos de animales con recuentos plaquetarios normales. No hubo diferencias significativas en ninguno de los índices entre los grupos trom...

Cytomegalovirus (CMV) is one of the most important intrauterine infections that cause birth defects in humans with hematogenous transmission rate of 0.5% to 2.5%, on average. The early transmission of infection from mother to fetus decreases the prognosis and increases the chances of serious anomalies. The objective of this case report is to instruct the neonatologist that despite the rarity of neonatal cholestasis, this may be a case of intrahepatic cholestasis resulting from congenital cytomegalovirus infection. This study aims to report the case of a 28 weeks and 6 days old child, presenting 1080 g birth weight, Apgar score 5 and 8, untreated sepsis, thrombocytopenia, leukocytosis, and jaundice with predominance in the evolution of direct bilirubin. To find out the cause of jaundice, serum bilirubin levels, serology and PCR (polymerase chain reaction) were performed for cytomegalovirus. Serology for cytomegalovirus was negative in spite of the molecular analysis by PCR in urine samples having demonstrated consistent results with the identification of genomic sequences of cytomegalovirus. Bilirubin values were: Total 15.58 mg%; Direct 12.36 mg%. It was concluded that treatment with ganciclovir resulted in satisfactory clinical response to treatment of cholestatic jaundice source cytomegalovirus.

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La historia se estudia o se aprende o cual de estas partes del binomio deben poner el acento los especialistas ¿Ser historiador garantiza como enseñar? ¿Los maestros de historia deben conocer la manera en como se investiga y se escribe? estas y muchas más interrogantes se atienden en este libro.

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